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ProteomicsDifferential UBE2H-CTLH E2-E3 ubiquitylation modulesregulate erythroid maturation
The developmentof haematopoietic stem cellsinto mature erythrocytes–erythropoiesis –is a controlled process characterized by cellular reorganisation and drastic reshaping of the proteome landscape.Failure of ordered erythropoiesis isassociated with anaemias and haematological maligna...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031992 | Pride
Ube2h Proteomics Dia Ms Gid complex Ubiquitination E2 Ctlh complex E3 
UnknownModular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation.
Not available
S-EPMC9718529 | biostudies-literature
UnknownUbiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Not available
S-EPMC8146699 | biostudies-literature
UnknownA heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish.
Not available
S-EPMC10199504 | biostudies-literature
UnknownMultisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Not available
S-EPMC10843684 | biostudies-literature
ProteomicsCryo-EM visualizes substrate channeling and E2 multisite phosphorylation configuring ubiquitin ligation by GID/CTLH E3
Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular principles governing many important E3-E2 partnerships remain unknown, including for RING-family GID/CTLH E3 ubiquitin ligases and their dedicated E2, Ubc8/UBE2H (yeast/human nomenclature). GID/CTLH-Ubc8/UBE2H-mediat...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD043646 | Pride
Proteomics 
UnknownIntegrated scRNA-seq and transcriptome analyses uncover the effects of UBE2H on the immune microenvironment regulation in pancreatic cancer.
Not available
S-EPMC12645782 | biostudies-literature
UnknownAn integrative analysis of transcriptome, methylome and single-cell RNA sequencing data identifies UBE2H as a marker of oxaliplatin resistance in colorectal cancer.
Not available
S-EPMC12577093 | biostudies-literature
GenomicsPredictive potential of circulating Ube2h mRNA as an E2 ubiquitin-conjugating enzyme for diagnosis or treatment of Alzheimer’s disease
Predictive potential of circulating Ube2h mRNA as an E2 ubiquitin-conjugating enzyme for diagnosis or treatment of Alzheimer’s disease
PRJNA616376 | ENA
TranscriptomicsPredictive potential of circulating Ube2h mRNA as an E2 ubiquitin-conjugating enzyme for diagnosis or treatment of Alzheimer’s disease
Neurodegenerative disorders are status in which neuronal cell death, miscommunications between synapse, and abnormal accumulation of proteins in the brain. Alzheimer’s disease (AD) is one of the age-related disorders which is most common degenerative disorders today, and strongly involved memory con...
ORGANISM(S): Mus musculus 
2020-12-31 | GSE147792 | GEO
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