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Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
ProteomicsNovel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development
In most species, early germline development occurs in the absence of transcription with germline determinants subject to complex translational and post-translational regulations. Here, we report for the first time that early germline development is influenced by dynamic regulation of the proteasome ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-04-10 | PXD013446 | Pride
Germline development Dnd1 Xenopus Oocyte-to-embryo transition Ubiquitin-independent proteasome 
UnknownNUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome.
Not available
S-EPMC12285911 | biostudies-literature
UnknownFlexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal.
Not available
S-EPMC2963393 | biostudies-literature
UnknownNub1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome.
Not available
S-EPMC11195292 | biostudies-literature
Unknown19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation.
Not available
S-EPMC11741298 | biostudies-literature
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
Unknown19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism.
Not available
S-EPMC12432587 | biostudies-literature
UnknownStress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.
Not available
S-EPMC9163039 | biostudies-literature
UnknownBimodular architecture of bacterial effector SAP05 that drives ubiquitin-independent targeted protein degradation.
Not available
S-EPMC10710061 | biostudies-literature
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