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ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
GenomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
PRJNA1198056 | ENA
ProteomicsNovel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development
In most species, early germline development occurs in the absence of transcription with germline determinants subject to complex translational and post-translational regulations. Here, we report for the first time that early germline development is influenced by dynamic regulation of the proteasome ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-04-10 | PXD013446 | Pride
Germline development Dnd1 Xenopus Oocyte-to-embryo transition Ubiquitin-independent proteasome 
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
TranscriptomicsProteasome inhibition blocks estrogen-dependent gene transcription by decreasing histone H2B monoubiquitination in human breast cancer cells
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate est...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30931 | biostudies-arrayexpress
GenomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo sapiens 
2025-03-19 | GSE284241 | GEO
UnknownStructural insights into the ubiquitin-independent midnolin-proteasome pathway.
Not available
S-EPMC12088389 | biostudies-literature
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
Unknown19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation.
Not available
S-EPMC11741298 | biostudies-literature
UnknownNUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome.
Not available
S-EPMC12285911 | biostudies-literature
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