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GenomicsPromoters Active in Interphase are Bookmarked during Mitosis by Ubiquitination
We analyzed genome-wide modification of chromatin by ubiquitination in human cells and whether this mark changes through the cell cycle using modified ChIP-seq technique (ChAP-seq). Chromatin affinity purification was based on a standard ChIP method with modification of a two-step affinity purificat...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45771 | biostudies-arrayexpress
GenomicsThe Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination
The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and ...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-59518 | biostudies-arrayexpress
MetabolomicsB-cell Translocation Gene 2 Inhibits UFMylation Modification of FMO1 thus Restricting Taurine Synthesis and Exacerbating Ferroptosis in Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion (I/R) injury is a common complication occurs during liver transplantation. However, the mechanisms underlying hepatic I/R injury have not been fully elucidated. B-cell translocation gene 2 (Btg2) has been implicated in the development of various diseases. However, its...

2026-03-07 | MTBLS11677 | MetaboLights
ProteomicsCalcium-triggered (de)ubiquitination events in synapses
Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation cascades. However, little is known about other post-translational modifications, as ubiquitination. To address ...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2025-04-19 | PXD053470 | panorama
ProteomicsIdentification of ubiquitination sites on protein CSDE1 in SHSY5Y cells.
This bottom-up proteomics dataset provides a global map of post-translational modifications (PTMs) on the RNA-binding protein CSDE1 in human neuroblastoma SHSY5Y cells. The data was acquired to survey the modification landscape of CSDE1, with a particular observation that lysine (K) residues display...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD073844 | Pride
Mkrn2 Csde1 Ubiquitination site 
ProteomicsMass-Spectrometric analysis of SdeA Ubiquitin modification and Ubiquitination
Conventional ubiquitination involves the ATP-dependent formation of amide bonds between the ubiquitin C-terminus and primary amines in substrate proteins. Recently, SdeA, an effector protein of pathogenic Legionella pneumophila, was shown to mediate NAD-dependent and ATP-independent ubiquitin transf...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD005240 | Pride
Legionella pneumophila Etd Orbitrap fusion 
ProteomicsProtein ubiquitination in Aspergillus nidulans
Protein ubiquitination, an evolutionarily conserved post-translational modification process in eukaryotes, and plays an important role in many biological processes. Aspergillus nidulans, a model filamentous fungus, contributes to our understanding of cellular physiology, metabolism and genetics, but...
ORGANISM(S): Aspergillus 
2015-09-10 | PXD002299 | Pride
Lc-msms Aspergillus nidulans Ubiquitination Mycelial dvelopment 
ProteomicsQuantitative proteomics reveals extensive lysine ubiquitination in Arabidopsis thaliana
In this study, we describe an antibody-based approach to enrich ubiquitinated peptides from vegetative tissues for detection via peptide mass spectrometry. This enrichment method can be coupled with isobaric labeling to enable quantification from up to 18-multiplexed samples. This approach identifie...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2024-07-31 | MSV000095496 | MassIVE
ProteomicsAn impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters
We integrated metabolome and proteome profiles of the parental cell line 143B.TK- versus ?0, including PTM analyses such as phosphorylation and ubiquitination to characterize the impact of the absence of mtDNA for the entire cell. For quantitative proteome profiling, we used a shotgun LC-MS/MS appro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080873 | MassIVE
ProteomicsPosttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination
Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects. Two major pathways regulate G-protein activity: canonical switching of the nucle...
ORGANISM(S): Hordeum vulgare (Barley) 
2021-11-02 | PXD019273 | Pride
Rho-type g-protein Ubiquitination Phosphorylation Barley 
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