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GenomicsIntegrative proteomics reveals increased non-degradative ubiquitylation during CD4+ T cell activation
Integrative proteomics reveals increased non-degradative ubiquitylation during CD4+ T cell activation
PRJNA526619 | ENA
ProteomicsHuwe1-mediated ubiquitylation of Dvl defines a novel negative feedback loop in the Wnt signaling pathway
Wnt signaling plays a central role in development, adult tissue homeostasis and cancer. Several steps in the canonical Wnt/b-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization or protein-protein interactions of ta...
ORGANISM(S): Mus musculus (Mouse) 
2014-05-28 | PXD000781 | Pride
Dvl Wnt signaling Ubiquitylation 
TranscriptomicsIntegrative proteomics reveals increased non-degradative ubiquitylation during CD4+ T cell activation
In spite of gathering evidence that ubiquitylation can direct non-degradative outcomes, most investigations of ubiquitylation in T cells remain focused on degradation. Here we integrated proteomic and transcriptomic datasets to establish a framework for predicting degradative or non-degradative outc...
ORGANISM(S): Mus musculus 
2020-03-11 | GSE128154 | GEO
ProteomicsVariation in auxin sensing guides AUX/IAA repressor ubiquitylation and destruction
Auxin is a drug-like small molecule and morphogen that triggers the formation of SCFTIR1/AFB-AUX/IAA co-receptor complexes leading to ubiquitylation and proteasome-dependent degradation of AUX/IAA transcriptional repressors in plants. Here, we systematically dissect auxin sensing by SCFTIR1-IAA6 and...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-06-14 | PXD004027 | Pride
Phytohormone Ubiquitylation Auxin Scf-type e3 ligase Ubiquitination Tir1/afbs Proteolysis Aux/iaa 
ProteomicsUbiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
The GID/CTLH E3 ligase complex is implicated in several biological processes, yet its full substrate repertoire remains poorly defined. We recently identified the complex as a broad modulator of macrophage responses to Mycobacterium tuberculosis (Mtb) infection. Here, we use label-free proteomics a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-24 | PXD075792 | Pride
Metabolism Innate immunity Ubiquitylation Tuberculosis Gid/ctlh complex Macrophages 
ProteomicsGlobal ubiquitylation analysis of mitochondria in primary neurons following PINK1-dependent activation of Parkin
Dataset analyzed in "Global ubiquitylation analysis of mitochondria in primary neurons following PINK1-dependent activation of Parkin" paper. Experiment TMT-labeled neurons untreated vs 5h AO treatment: 1) Membrane Proteome: .raw files AO2445-AO2456 2) Ubiquitylome: .raw files AO2433-AO2438 Experi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-06-16 | MSV000087639 | MassIVE
GenomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [ChIP-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53206 | biostudies-arrayexpress
TranscriptomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [RNA-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53207 | biostudies-arrayexpress
ProteomicsConvergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-Treated Yeast Cells
Protein, Ubiquitylation, and Phosphorylation changes were quantified after 1 and 3 hours of rapamycin treatment in budding yeast. Approximately 3,600 proteins, 9,000 phosphorylation sites, and 2,500 ubiquitylation sites were quantified.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-10-03 | PXD000554 | Pride
Proteome Tor Ubiquitylation Rapamycin Phosphorylation 
ProteomicsGlobal profiling of lysine ubiquitylation in human hypothalamus
In this study, we employed LC‒MS/MS to generate a comprehensive profile of ubiquitylation in the human hypothalamus under normal physiological conditions. Our findings will contribute to further exploration of the role of ubiquitylation in various physiological and pathological processes, particular...
ORGANISM(S): Homo Sapiens 
2024-02-24 | PXD050124 |
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