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ProteomicsAffinity purification MS of human Ubiquitin-tagged RIT1
Human RIT1 was tagged with HA tag + N or C terminal ubiquitin (HA-Ubiqutin-RIT1 and HA-RIT1-Ubiqutin) and compared with empty vector (EV) or S35N/M90I RIT1 mutant (HA-RIT1 S35N/M90I). The constructs were expressed in human 293T cells and affinity purified using HA beads. RIT1 interacting proteins we...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD047228 | Pride
Human Ubiquitin Rit1 
TranscriptomicsTranscriptome analysis among young and senescent fibroblasts
We carried out the analysis using human skin fibrobllast HCA2 (MJ90) cells. Cells were indcued to be senescent cells by treatment with RO3306 and Nutlin3a. The transcriptome analysis between young cells (uniduced cells) nd senescent cells revealed lonrf2, a ubiqutin E3 ligase, is one of the genes hi...
ORGANISM(S): Homo sapiens 
2023-07-20 | GSE179465 | GEO
UnknownSilencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells.
Not available
S-EPMC6978385 | biostudies-literature
ProteomicsCUL4A-DDB1-DCAF10 is an n-recognin for Nt-acetylated Src kinases
cotranslational n-terminal modifications such as methionine excision, acetylation, and myristoylation contribute to protein stability, localization and three-dimensional folding. Disruption of these modifcations expose short n-terminal degron motifs that ultimately trigger protein degradation throug...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD061095 | Pride
N-t acetylation Sfks N-degron dcaf10 Ubiquitination Nt- myristoylation Cotranslational modifications N-recognin 
ProteomicsAn ERAD independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER) where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated-degradation (ERAD) remove...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
MSV000090333 | MassIVE
GenomicsCP190 and CTCF mediated enhancer blocking is augmented by SUMOylation
Chromatin insulators shield promoters and chromatin domains from neighbouring enhancers or chromatin regions with opposing activities. Insulator binding proteins and their cofactors mediate the boundary function. In general, covalent modification of proteins by the Small Ubiqutin-like Modifier (SUMO...
ORGANISM(S): Drosophila melanogaster 
2017-08-07 | GSE96581 | GEO
ProteomicsSerpinc1 acts as a tumor suppressor in hepatocellular carcinoma through inducing apoptosis and blocking macrophage polarization in an ubiquitin-proteasome manner
Serpinc1 is a serine protease inhibitor in the coagulation cascade, but its role in tumor biology remains obscure. Here, we report an unexpected role of serpinc1 in suppression of hepatocellular carcinoma (HCC). In HCC patients, the mRNA and protein expression of serpinc1 is up-regulated, which is n...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026782 | Pride
Serpinc1  apoptosis  liver cancer  macrophage  ubiquitination 
UnknownEnhanced expression of rabies virus surface G-protein in Escherichia coli using SUMO fusion.
Not available
S-EPMC7087916 | biostudies-literature
UnknownFbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3.
Not available
S-EPMC7808939 | biostudies-literature
UnknownGartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy.
Not available
S-EPMC6946862 | biostudies-literature
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