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ProteomicsUBQLN4, a regulator of protein dynamics at sites of DNA damage, is lost in a new genome instability syndrome and elevated in aggressive tumors
The ubiquitin-proteasome system (UPS) plays a crucial role in cellular homeostasis, but the mechanistic aspects of its involvement in the DNA damage response (DDR) remain largely elusive. Here, we identify a homozygous truncation mutation in the UBQLN4 gene in families with highly pleiotropic autoso...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD008299 | Pride
Dna damage Lc-ms Proteomics Ubqln4 
ProteomicsUBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors
The ubiquitin-proteasome system (UPS) plays a crucial role in cellular homeostasis and its major role in genome stability and maintenance is rapidly emerging. Here, we identify the proteasomal shuttle factor ubiquilin-4 (UBQLN4) as a major component of the DNA damage response. We found a homozygous ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-12 | PXD011488 | Pride
Cancer Phosphorylation Dna-damage 
UnknownA novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis.
Not available
S-EPMC5451210 | biostudies-literature
UnknownUBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.
Not available
S-EPMC5278606 | biostudies-literature
UnknownUBQLN4 is activated by C/EBPβ and exerts oncogenic effects on colorectal cancer via the Wnt/β-catenin signaling pathway.
Not available
S-EPMC8688525 | biostudies-literature
UnknownUBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Not available
S-EPMC8637560 | biostudies-literature
UnknownRegulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma.
Not available
S-EPMC8024730 | biostudies-literature
UnknownCirc_0000006 and circ_0000160 regulate hsa-let-7e-5p/UBQLN4 axis in aortic dissection progression.
Not available
S-EPMC11142605 | biostudies-literature
UnknownShort N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4.
Not available
S-EPMC10557701 | biostudies-literature
ProteomicsUbiquilin interactomes from Fly
Mutations in Ubiquilins, UBQLN2, and UBQLN4 cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearance is poorly defined. Here, we performed Ubqn-GFP pull down from fly samples to find Ubqn binding partners.
ORGANISM(S): Drosophila <fruit Fly, Genus> (ncbitaxon:7215) 
2018-12-18 | MSV000083259 | MassIVE
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