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MetabolomicsSerum lipidomic profile of cold-exposed Ucp1cre/12-LOX KO mice
Not available
ORGANISM(S): Mus musculus 
ST001213 | MetabolomicsWorkbench
ProteomicsUCP1-dependent depletion of liver extracellular succinate antagonizes inflammatory pathogenesis
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver pathology worldwide and is intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD and is thought to contribute to tissue fibrosis and disease pathogenesis. Uncoupling protein 1 (UCP1) is excl...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD024717 | Pride
Inflammation Thermogenesis Ucp1 Liver Bat 
TranscriptomicsA Smooth Muscle-Like Origin for Beige Adipocytes
A comparison of the translating RNAs in UCP1-positive cells from the classical BAT, the inguinal WAT, and the perigonadal WAT. We find genes common to all UCP1-positive cells independent of anatomical location, as well as genes specifically enriched in one group versus the others. Results provide a ...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-56248 | biostudies-arrayexpress
ProteomicsCysteine 253 of UCP1 regulates energy expenditure and adipose tissue inflammation
Uncoupling protein 1 (UCP1) is thought to be a major regulator of whole-body energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss of function model has recently been shown to have destructive effects on the entire electron transport chain of thermogenic fat. As such, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-15 | PXD029270 | Pride
Sex-dependent Thermogenesis Inflammation Ucp1 Adipose 
ProteomicsFacultative protein selenation controls redox sensitivity, adipose tissue thermogenesis and obesity
Oxidation of cysteines by reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenols, where sulfur is replaced with selenium, exhibit enhanced reactivity with ROS. Here we developed a mass spectrometric method to interrogate incorporation of selenols ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018225 | Pride
Ucp1 Thermogenesis Selenium 
GenomicsFGF21 in UCP1-deficient mice
FGF21 mediates the “paradoxical” resistance to diet-induced obesity in UCP1-deficient mice
PRJEB28632 | ENA
TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
ProteomicsSIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1 

Objective: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a possible functional connection between UCP1 and s...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-18 | PXD013056 | Pride
Brown adipose tissue  thermogenesis  thermoregulation  mitochondria  uncoupling protein 1  sirtuin 3  acetylation  oxidative phosphorylation  fatty acid oxidation  acylcarnitines 
 
GenomicsRNA-Sequencing of wild type and UCP1-null beige adipose tissue
RNA-Sequencing of wild type and UCP1-null beige adipose tissue
PRJEB11892 | ENA
GenomicsscATAC-seq of Inguinal Adipose Tissue of UCP1-KO and WT mice.
scATAC-seq of Inguinal Adipose Tissue of UCP1-KO and WT mice.
PRJNA729995 | ENA
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