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ProteomicsQuantitative proteome analysis to map the targets of small molecule UM171
Earlier we identified the protein degradation properties of small molecule UM171 (Subramaniam et al., 2020, Blood). Here we employed quantitative proteomics approach to map the global targets of UM171. Our study revealed multiple targets including the members of CoREST complex such as RCOR1 and LSD1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD037999 | Pride
Um171 Protein degradation. Corest 
TranscriptomicsTranscriptome data of CD34+ human cord blood-derived cell treated with UM171, SR1 or both
mRNA profiling of CD34+ human cord blood-derived cell treated with UM171, SR1 or both mRNA profiles of CD34+ human cord blood-derived cell treated with DMSO (control), SR1 [500nM], UM171 [35nM] or combination SR1 [500nM]+ UM171 [35nM] for 30min, 3hr, 12hr, 24hr, 48hr, 72hr were generated by deep s...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-57299 | biostudies-arrayexpress
TranscriptomicsRNA expression profiling of human mPB or CB-derived CD34+ cells treated with UM171 at different doses
RNASeq data for mPB or CB-derived CD34+ exposed to UM171 human mobilized peripheral blood or cord blood-derived CD34(+) cells were cultured for 16 hours with vehicle (DMSO), dose response of UM171 [11.9nM, 19nM, 30.5nM, 48.8nM, 78.1nM and 125nM], SR1 [500nM] and combination of( UM171 [48.8nM]+SR1 ...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-57561 | biostudies-arrayexpress
ProteomicsQuantitative proteome analysis to map the targets of small molecule UM171
Earlier we identified the protein degradation properties of small molecule UM171 (Subramaniam et al., 2020, Blood). Here we employed quantitative proteomics approach to map the global targets of UM171. Our study revealed multiple targets including the members of CoREST complex such as RCOR1 and LSD1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-26 | PXD038013 | Pride
Um171 Protein degradation. Corest 
GenomicsAML5_DMSO vs UM171
AML5_DMSO vs UM171
PRJNA591592 | ENA
GenomicsUM171 effect in AML1 cells in KBTBD4 null context
UM171 effect in AML1 cells in KBTBD4 null context
PRJNA660784 | ENA
UnknownUM171 suppresses breast cancer progression by inducing KLF2.
Not available
S-EPMC11297059 | biostudies-literature
TranscriptomicsAML5_DMSO vs UM171
UM171 effect on AML5 cell lines (kinetic)
ORGANISM(S): Homo sapiens 
2019-11-25 | GSE138487 | GEO
UnknownUM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Not available
S-EPMC11882444 | biostudies-literature
UnknownUM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression.
Not available
S-EPMC9637110 | biostudies-literature
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