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UnknownTreatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis.
Not available
S-EPMC7472604 | biostudies-literature
ProteomicsDevelopment of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics
Liquid handling robots have been developed to automate various steps of the bottom-up proteomics workflow, however, protocols for the generation of isobarically labeled peptides remain limited. Existing methods often require costly specialty devices and are constrained by fixed workflows. To address...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD060786 | Pride
Automation Sample preperation Unfolded protein response and tandem mass tags 
ProteomicsComparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies
Human coronaviruses (hCoV) have become a threat to global health and society, as evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent COVID-19 pandemic caused by SARS-CoV-2. Despite high sequence similarity between SARS-CoV-1 and -2, each strain has distinctive virulence. ...
ORGANISM(S): Severe acute respiratory syndrome-related coronavirus Homo sapiens (Human) Betacoronavirus 
2020-12-03 | PXD022017 | Pride
Nsp2 Mitochondria-associated endoplasmic reticulum membrane Affinity purification-mass spectrometry Non-structural proteins Covid-19 Tandem mass tags Nsp4 
ProteomicsStructural Alternation in Heat Shock Proteins of Activated Macrophages
The inflammatory response of macrophages is an orderly and complex process under strict reg-ulation accompanied by drastic changes in morphology and functions. It is predicted that pro-teins will undergo structural changes during these finely regulated processes. However, changes in structural prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029672 | Pride
Structural proteomics  raw264.7  lps  lip-ms  hsp60 
UnknownProteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.
Not available
S-EPMC11528127 | biostudies-literature
ProteomicsUBXN1 maintains ER proteostasis and represses UPR activation by modulating translation
ER protein homeostasis (proteostasis) is essential to facilitate proper folding and maturation of proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of misfolded or aberrant proteins in the ER and triggers the unfolded protein response (UPR). Here we find that th...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043686 | Pride
Ubxn Tmt Upr Er stress Proteostasis 
ProteomicsCombined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
Background: Muscle proteins of the obscurin protein family play important roles in sarcomere organization, sarcoplasmic reticulum (SR) and T-tubule architecture and function. However, their precise molecular functions and redundancies between protein family members as well as their involvement in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058697 | Pride
Mouse heart muscle itraq obscurin 
ProteomicsAstrocytes modulate neuronal development by S100A6 signaling
Neuronal morphogenesis relies on intercellular signaling. Astrocytes release metabolites, trophic, and guidance factors to promote neuronal maturation. In contrast, the mechanisms by which astrocytes could limit and stabilize neuronal connectivity remain less explored. Here, we find cortical astroc...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD066923 | Pride
Calcyclin calcyclin-binding protein morphogenesis cerebral cortex intercellular commu-48 nication upr pathway. 
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