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MetabolomicsKidney Tissue Targeted Metabolic Profiling of Unilateral Ureteral Obstruction Rats by NMR
Renal interstitial fibrosis is a common pathological process in the progression of kidney disease. A nuclear magnetic resonance (NMR) based metabolomics approach was used to analyze the kidney tissues of renal interstitial fibrosis (RIF) rats, induced by unilateral ureteral obstruction (UUO). The co...
2017-10-09 | MTBLS361 | MetaboLights
TranscriptomicsMurine Kidney Tissue: Unilateral ureteral obstructed mice vs. Sham control
INTRODUCTION AND OBJECTIVE: Loss of renal function is often the impetus for operative intervention in renal obstruction. Obstructive nephropathy is characterized discrete morphological and physiologic changes including tubular dilatation, apoptosis, and atrophy, as well as interstitial cellular inf...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36496 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis revealed novel genes and pathways associated with neonatal unilateral ureteral obstruction
Congenital obstructive nephropathy (CON) is the leading cause of pediatric chronic kidney diseases with high morbidity and mortality.To identify differentially expressed genes, microarray analysis was performed using the unilateral ureteral obstruction (UUO)-induced neonatal rat model of CON.
ORGANISM(S): Rattus norvegicus 
2017-01-26 | E-MTAB-4984 | biostudies-arrayexpress
ProteomicsReduced collagen degradation in pelvic urine precedes kidney fibrosis induced by unilateral ureteral obstruction
Kidney fibrosis is a major hallmark of chronic kidney disease and is defined by an excessive accumulation of extracellular matrix, primarily collagens. While collagen synthesis has been extensively investigated, the contribution of impaired collagen degradation to the development of fibrosis remains...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD064569 | Pride
Chronic kidney disease Kidney fibrosis Urine Unilateral ureteral obstruction Ce-ms/ms 
ProteomicsExpression profiles of kidney mitochondrial proteome during the progression of the unilateral ureteral obstruction: focus on energy metabolism adaptions.
Obstructive nephropathy (ON) is a common clinical entity caused by different etiologies such as urolithiasis, prostatic hyperplasia in males, tumors, congenital stenosis, and others. Unilateral ureteral obstruction (UUO) in rodents is an experimental model widely used to explore the pathophysiology ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-18 | PXD036205 | Pride
Kidney fibrosis Mitochondria proteome Energy metabolism. Unilateral ureteral obstruction (uuo) 
GenomicsAxl targeting in experimental unilateral ureteral obstruction
Axl targeting in experimental unilateral ureteral obstruction
PRJNA509498 | ENA
ProteomicsTMT-based proteome and phosphoproteome profile of unilateral ureteral obstruction
TMT-based proteome and phosphoproteome sequencing technology was performed on normal or unilateral ureteral obstruction samples to explore the potential mechanism and identify valuable diagnostic and therapeutic targets.
ORGANISM(S): Mus Musculus 
2022-07-13 | PXD035286 |
TranscriptomicsProfiling of miRNA expression in mouse SHAM kidneys
Profiling of miRNA expression in mouse SHAM kidneys 9–12 weeks old male C57BL/6 mice were purchased from Charles River. Mice underwent anesthesia by intraperitoneal injection of pentobarbital (50 mg/kg body weight) and were subjected to Unilateral Ureteral Obstruction (UUO). After standard laparotom...
ORGANISM(S): Mus musculus 
2013-08-31 | E-GEOD-39831 | biostudies-arrayexpress
GenomicsExpressions of MicroRNA in Mouse Kidney with Unilateral Ureteral Obstruction
Expressions of MicroRNA in Mouse Kidney with Unilateral Ureteral Obstruction
PRJNA683028 | ENA
TranscriptomicsTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Tissue inhibitors of metalloproteinases (TIMP) are endogenous inhibitors of matrix metalloproteinases (MMP). While TIMP2 and TIMP3 inhibit MMPs, TIMP3 also inhibits activation of pro-MMP2 whereas TIMP2 promotes it. Here we assessed the differential role of TIMP2 and TIMP3 in renal injury using the u...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-42303 | biostudies-arrayexpress
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