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TranscriptomicsMechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis
Data from clinical studies, cell culture, and animal models implicate the urokinase (uPA)/Plasminogen (Plg) system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/Plg stimulate these diseases are not yet defined. We used genetically modified, atherosc...
ORGANISM(S): Mus musculus 
2011-05-03 | E-GEOD-29028 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of 4T1 tumors expressing mouse urokinase plasminogen activitor (uPA)
Analysis of uPA regulation of 4T1 tumor growth at gene expression level. The hypothesis tested in the present study was that overexpression of uPA in 4T1 tumor influence the tumor growth and metastasis related cell signaling pathway. 4T1 cells were stably transduced by lentiviral vector expressing m...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-38346 | biostudies-arrayexpress
ProteomicsWild-type and O/E uPA in mouse aortic arches_PROTOMAP
Aortic arches from WT and overexpression of uPA were extracted and their proteome was processed and subjected to PROTOMAP analysis.
ORGANISM(S): Mus musculus (Mouse) 
2020-08-10 | PXD020406 | Pride
Protomap Aortic arches Upa 
TranscriptomicsInhibition of uPA expression by CRISPR-dCas9 DNA methyltransferases
We report the generation of CRISPR-dCas9 DNA methyltransferases to mediate targeted DNA methylation. Using the dCas9-BFP-DNMT3A and dCas9-BFP-DNMT3B methyltransferases, we have demonstrated that these two methyltransferase can mediate targeted methylation in three human genes tested: uPA, TGFBR3, an...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-74935 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ovaries collected from mice treated with or without Ulipristal
Ulipristal acetate (UPA), also referred to as VA/CDB-2914, is a new and promising emergency contraceptive. It is a selective progesterone receptor modulator (SPRM) that has been approved in Europe and the USA for emergency contraception. To experimentally induce ovulation, the immature CD-1 mice (24...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-37353 | biostudies-arrayexpress
ModelsVenkatraman2011 - PLS-UPA behaviour in the presence of substrate competition_1_1_1_1
Venkatraman2011 - PLS-UPA behaviour in the presence of substrate competition The posibility of ultrasensitivity and bistable activation of PLS (Plasmin) and UPA (Urokinase-type plasminogen activator) in the presence of substrate competition is explained here using a mathematical model.  ...
2024-09-02 | BIOMD0000000630 | BioModels
TranscriptomicsMechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis
Data from clinical studies, cell culture, and animal models implicate the urokinase (uPA)/Plasminogen (Plg) system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/Plg stimulate these diseases are not yet defined. We used genetically modified, atheroscle...
ORGANISM(S): Mus musculus 
2011-05-03 | GSE29028 | GEO
GenomicsUPA-Seq: Prediction of functional lncRNAs using the sensitivities to UV-crosslinking
UPA-Seq: Prediction of functional lncRNAs using the sensitivities to UV-crosslinking
PRJNA472627 | ENA
TranscriptomicsGene expression analysis of 4T1 tumors expressing mouse urokinase plasminogen activitor (uPA)
Analysis of uPA regulation of 4T1 tumor growth at gene expression level. The hypothesis tested in the present study was that overexpression of uPA in 4T1 tumor influence the tumor growth and metastasis related cell signaling pathway.
ORGANISM(S): Mus musculus 
2012-05-31 | GSE38346 | GEO
UnknownTEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.
Not available
S-EPMC6151050 | biostudies-literature
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