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TranscriptomicsTranscription profiling of mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin
Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatmen...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8682 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin
Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatmen...
ORGANISM(S): Mus musculus 
2008-01-11 | GSE8682 | GEO
UnknownStress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Not available
S-EPMC4538794 | biostudies-literature
UnknownActivating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells.
Not available
S-EPMC11447041 | biostudies-literature
ProteomicsGlobal proteome analysis of ATF4 targets during ER stress.
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as well as disease states, including cancer. Since UPR can serve as a lever betwe...
ORGANISM(S): Homo sapiens (Human) 
2019-07-22 | PXD012858 | Pride
Human Lncap cells Lc-ms 
UnknownImbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity.
Not available
S-EPMC10336013 | biostudies-literature
TranscriptomicsRNA profiling of wild-type Osteosarcoma (U2OS) cells and its KO derivative (PERK KO) upon Palbociclib treatment for 4 days
Dysregulation of cyclin-dependent kinase 4/6 (CDK4/6) occurs in various cancers. Three CDK4/6 inhibitors are approved for clinical use including Palbociclib (PD). CDK4/6 inhibitors trigger early G1 cell cycle arrest in cells, leading to cellular quiescence while long term inhibition enforces transit...
ORGANISM(S): Homo sapiens 
2026-04-30 | GSE294635 | GEO
TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
UnknownInhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
Not available
S-EPMC11185543 | biostudies-literature
UnknownDDRE-06. CELLULAR STRESS RESPONSE IN DIPG THERAPY
Not available
S-EPMC7650490 | biostudies-literature
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