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MetabolomicsCreatine uptake promotes dendritic cell activation and enhances antitumor immunity

Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (CrT; Slc6a8) in intratumora...

2026-03-11 | MTBLS12797 | MetaboLights
MetabolomicsPronounced uptake and metabolism of organic substrates by diatoms revealed by pulse-labeling metabolomics
Diatoms contribute as a major group of microalgae to approximately 20% of the global carbon fixation. In the plankton, these algae are exposed to a plethora of metabolites, especially when competing algae are lysed. In line with evidence that these phototrophs can also engage in heterotrophy we aske...
2021-12-09 | MTBLS2333 | MetaboLights
MetabolomicsInvestigating diet to control asparagine uptake as an adjunct to asparaginase treatment

Refinements of multidrug regimens, and particularly the addition of L-asparaginase, resulted in an immediate gain in survival for pediatric acute lymphoblastic leukemia patients. Yet L-asparaginase has substantial side effects which may require dose reductions or delays in subsequent doses. There...

2026-01-25 | MTBLS13764 | MetaboLights
MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
MetabolomicsBenthic exometabolites and their ecological significance on threatened Caribbean coral reefs (Metabolite uptake incubation assay)

Benthic organisms sustain coral reefs through their growth and metabolism, but less is known about how their released metabolites influence reef seawater microorganisms. To investigate metabolite composition of benthic exudates and their ecological significance for reef microbial communities, we ...

2022-08-22 | MTBLS3286 | MetaboLights
MetabolomicsGlycine betaine uptake and metabolism in marine microbial communities
Not available
ORGANISM(S): Natural mixed marine microbial community 
ST002008 | MetabolomicsWorkbench
MetabolomicsInhibition of diamine oxidase promotes uptake of putrescine from rat small intestine
Not available
ORGANISM(S): Rattus norvegicus 
ST000401 | MetabolomicsWorkbench
MetabolomicsE.coli effects on growth and substrate uptake of green algae (part I - HILIC)
Not available
ORGANISM(S): Escherichia coli 
ST000399 | MetabolomicsWorkbench
MetabolomicsE.coli effects on growth and substrate uptake of green algae (part II - Reverse Phase)
Not available
ORGANISM(S): Escherichia coli 
ST000400 | MetabolomicsWorkbench
TranscriptomicsWRKY6 Transcription Factor Restricts Arsenate Uptake and Transposon Activation in Arabidopsis
Stress constantly challenges plant adaptation to the environment. Of all stress types, arsenic was a major threat during the early evolution of plants. The most prevalent chemical form of arsenic is arsenate, whose similarity to phosphate renders it easily incorporated into cells via the phosphate...
ORGANISM(S): Arabidopsis thaliana 
2014-04-25 | E-GEOD-49037 | biostudies-arrayexpress
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