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MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsUridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis

Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading 

to excessive bone resorption and microarchitectural deterioration. Although the interconnection 

between osteoclast differentiation and cellular energy metabolism has been inc...

2026-04-09 | MTBLS13394 | MetaboLights
MetabolomicsLow-Protein Diet Enhances Anti-Tumor Immunity in Pancreatic Cancer through Microbiota-Derived Uridine Diphosphate-Galactose
Low-protein diets (LPD) have been linked to improved metabolic health, but their role in pancreatic ductal adenocarcinoma (PDAC) immunotherapy remains unclear. Here we show that an LPD suppresses PDAC progression in male mice by remodeling the gut microbiota and activating anti-tumor immunity. LPD p...
2026-07-09 | MTBLS14989 | MetaboLights
ProteomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice
Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging remain unclear. Here, we show that uridine levels in the plasma and ovaries of aged mice are significantly red...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-05 | PXD075265 | Pride
Pcbp1 Ferroptosis Uridine Oocyte quality Advanced maternal age 
UnknownPalladium-catalyzed C-H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues.
Not available
S-EPMC9434382 | biostudies-literature
TranscriptomicsUridine Modulates Gene Expression Programs During RANKL-Induced Osteoclastogenesis in RAW264.7 Cells
Uridine has been implicated in the regulation of metabolic and redox processes, yet its transcriptional effects during osteoclast differentiation remain unclear. This dataset profiles global gene expression in RAW264.7 cells under three conditions: untreated control, RANKL-induced osteoclastogenesis...
ORGANISM(S): Mus musculus 
2026-04-09 | GSE311708 | GEO
GenomicsA Novel Combination Therapy with Uridine and Praziquantel effectively Alleviates Schistosomiasis-induced Hepatic Fibrosis through Promoting Adipogenic Differentiation
A Novel Combination Therapy with Uridine and Praziquantel effectively Alleviates Schistosomiasis-induced Hepatic Fibrosis through Promoting Adipogenic Differentiation
PRJNA1224445 | ENA
UnknownIndispensable residue for uridine binding in the uridine-cytidine kinase family.
Not available
S-EPMC5614712 | biostudies-literature
Transcriptomics4SU-iCLIP of MATR3 from HEK293 cells with or without PTBP1 depletion
The aim of the experiment was to compare binding of MATR3 in presence and absence of PTBP1. HEK293T cells were transfected with siRNA targeting PTBP1 and PTBP2 or control sequences and labelled with 4thio-uridine for 8 hours (100µM, crosslinking 2x400mJ/cm2 365nm UV light).
ORGANISM(S): Homo sapiens 
2018-05-01 | E-MTAB-6267 | biostudies-arrayexpress
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