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ProteomicsHuman Urinary Proteome in Vesicoureteral Reflux
Vesicoureteral reflux (VUR) is a common pediatric condition that predisposes children to renal damage after urinary tract infection (UTI). We profiled the urinary proteome of VUR patients with recurrent UTI and renal scarring to identify potential biomarkers characterizing this condition. Urine was...
ORGANISM(S): Homo sapiens (Human) 
2018-10-05 | PXD010469 | Pride
Kidney damage Urine Vesicoureteral reflux Urinary tract infection 
ModelsUhlén2015 - Human tissue-based proteome metabolic network - urinary
Uhlén2015 - Human tissue-based proteome metabolic network - urinary Human urinary track specific proteome metabolic network This model is described in the article: Tissue-based map of the human proteome Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinogl...
2015-01-28 | MODEL1411240031 | BioModels
ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080847 | MassIVE
ProteomicsUrinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy
Despite much promise to overcome drug-resistant infections, clinical studies of bacteriophage anti-bacterial therapy have failed to show durable effectiveness. Although lysogeny plays an important role in bacterial physiology, its significance in diverse microbiomes remains under-studied. Here, we t...
ORGANISM(S): Homo sapiens (Human) 
2025-01-17 | PXD059932 | Pride
Urinary tract infection Bacteriphages 
ProteomicsUrinary proteome of a healthy human cohort aged 70 to 82
12 urine samples from 6 individuals (2 time points each) enrolled in a study on healthy aging were collected. Samples were frozen at -80⁰C prior to analysis. Samples were thawed, pH neutralized, separated into soluble urine (SU) and urinary pellet (UP) fractions, and subjected to filter aided sample...
ORGANISM(S): Homo sapiens (Human) 
2017-05-03 | PXD004713 | Pride
Urine Urinary proteome Proteomics Urinary sediment Aging 
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella <scale Insect> (ncbitaxon:108061) Morganella <fungus> (ncbitaxon:90690) Pseudomonas Sp. (ncbitaxon:306) Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079927 | MassIVE
ProteomicsProteomic analysis identifies dysregulated proteins in albuminuria: a South African pilot study
Chronic kidney disease remains an unmet clinical challenge. It is only detected at advanced stages by current markers. Therefore, early detection of chronic kidney disease is vital. In this study, we profiled the urinary proteome in patients with albuminuria with well-preserved eGFR. We identi-fied ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054170 | Pride
Urinary proteomics  albuminuria  chronic kidney disease  biomarker Ne 
UnknownAn individual urinary proteome analysis in normal human beings to define the minimal sample number to represent the normal urinary proteome.
Not available
S-EPMC3544588 | biostudies-literature
ProteomicsUrine-HILIC – An automated sample preparation for bottom-up urinary proteome profiling in clinical proteomics
Urine provides a diverse source of information related to health status and is ideal for clinical proteomics because of its ease of collection. To date, there is no standard operating procedure for reproducible and robust urine sample processing for mass spectrometry-based clinical proteomics. To ad...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043925 | Pride
Automated sample preparation  clinical proteomics  swath-ms (dia)  urinary proteomics  hilic 
ProteomicsComprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Noninvasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model
To investigate the potential noninvasive early biomarkers of AD in 5XFAD mouse model, we investigate the proteome of urinary exosomes present in 1-month-old (before amyloid-β accumulation) 5XFAD mouse models and their littermate controls. Another two groups of 2 and 6 months-old urinary samples were...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021935 | Pride
Urinary exosome proteome Alzheimer’s disease 5xfad mouse model Early diagnosis Biomarkers 
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