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MetabolomicsDivalent Aptamer-mediated Clustering for Extracellular Vesicle Separation
Extracellular vesicles (EVs) are important mediators of intercellular communication and promising sources of diagnostic and therapeutic biomarkers, yet effective EV isolation remains challenging due to trade-offs among yield, purity, and adaptability across biofluids. Here, we introduce divalent apt...
2026-05-04 | MTBLS14425 | MetaboLights
MetabolomicsUrinary Extracellular Vesicle Metabolomic Profiling Reveals a Distinct Molecular Signature for the Non-Invasive Diagnosis of Lupus Nephritis

Background: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), underscoring an urgent need for non-invasive diagnostic biomarkers. 

Objective: This study aimed to define the metabolomic signature of urinary e...

2026-02-11 | MTBLS13839 | MetaboLights
TranscriptomicsFluidigm Biomark 96.96 nanofluidic arrays for qRT-PCR of 93 miRNAs: salivary extracellular vesicles
Crude extracellular vesicles (EVs) from eight healthy volunteers were separated into 6 fractions based on their densities by using the iodixanol-based density gradient centrifugation method. To determine the distribution of miRNAs among these fractions, quantities of 93 miRNAs were quantified by the...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-78763 | biostudies-arrayexpress
ProteomicsUrine Large Extracellular Vesicle LC-MS/MS Data from a Chronic Kidney Disease Rat Model
This study examined large renal tubule extracellular vesicles (LRT-EVs) isolated from urine of a 5/6 nephrectomy (5/6Nx) rat model that recapitulates many elements of human chronic kidney disease (CKD). Within weeks of 5/6Nx rats spontaneously exhibit proximal tubular damage including brush boarder...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-26 | PXD019207 | Pride
Extracellular vesicles Urine Kidney Lc-ms/ms 
GenomicsPerformance assessment of Total RNA sequencing of human biofluids and extracellular vesicles
RNA profiling has emerged as a powerful tool to investigate the biomarker potential of human biofluids. However, despite enormous interest in extracellular nucleic acids, RNA sequencing methods to quantify the total RNA content outside cells are rare. Here, we evaluate the performance of the SMARTer...
EGAS00001004428 | EGA
ProteomicsHost and Bacterial Urine Proteomics Might Predict Treatment Outcomes for Immunotherapy in Advanced NSCLC
Urine extracellular vesicles from NSCLC patients were analyzed via LC-MS/MS to identify host and microbial proteins associated with progression-free survival. The study included 33 baseline urine samples and follow-up data. Samples were processed using EVtrap and analyzed on a Q-Exactive HF-X using ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-10 | PXD062630 | Pride
Urine Proteomics Nsclc Lc-ms Extracellular vesicles Immunotherapy Host-microbiome 
ProteomicsUrine Extracellular Vesicles as a Non-Invasive Implantation Window Monitoring Method
Progress and advancement in assisted reproductive technologies (ART) and its outcomes are limited by the importance of research of endometrial receptivity being overlooked. Due to endometrial biopsy being invasive and in vitro studies lacking reproducibility in vivo, urine is an appealing alternativ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-04 | PXD047127 | Pride
Urine Extracellular vesicles Implantation 
TranscriptomicsRNA-associated to Urinary Vesicles as a Suitable Non-invasive Source for Diagnostic Purposes in Bladder Cancer
Bladder cancer is one of the most common cancers. Since prognosis ameliorates with early detection, it is a challenge to develop techniques that could replace or complement the current diagnosis protocols. The study of extracellular vesicles (EVs) that are present in urine samples has become an attr...
ORGANISM(S): Homo sapiens 
2014-01-29 | E-GEOD-51843 | biostudies-arrayexpress
ProteomicsUltrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine
Extracellular vesicles (EVs) have a great potential in clinical applications, however their isolation from different body fluids and their characterisation are not yet optimal or standardised. Here we report the results of examining the performance of ultrafiltration combined with size exclusion chr...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD009709 | Pride
Urine Extracellular vesicle Exosome Orbitrap Lc-ms/ms 
ProteomicsQuantitative proteomics analysis reveals a protein concentration effect of neat urine compared to urine EVs
Research in urine proteomics and extracellular vesicles (EV) has gained increasing traction in biomarker research. Previous studies have suggested that both can be affected by urine protein concentration, however, there is a lack of data on the combined effect on urine proteomics. Here, we assessed ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-11 | PXD056692 | Pride
Urine extracellular vesicles Proteinuria Kidney biomarkers Urine proteomics 
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