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ProteomicsTarget identification of usnic acid in bacterial and human cells
Usnic acid is a natural product with versatile biological activities against various organisms. We here utilize a chemical proteomic strategy to gain insights into its target scope in bacterial and human cells. First, we excluded DNA binding as a major reason for its antibacterial activity and secon...
ORGANISM(S): Homo sapiens (Human) Enterococcus faecalis (Streptococcus faecalis) 
2024-08-10 | PXD049013 | Pride
Abpp Usnic acid 
ProteomicsThe novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation
The formation of new ribosomes is tightly coordinated with cell growth and proliferation. In eukaryotes, the correct assembly of all ribosomal proteins and RNAs involves an intricate cascade of maturation and rearrangement steps across three cellular compartments: the nucleolus, nucleoplasm, and cyt...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD046691 | Pride
Yeast 60s Ribosome biogenesis Lc-msms 
UnknownData on (+)-usnic acid: A new application to treat toxoplasmosis.
Not available
S-EPMC4939410 | biostudies-literature
UnknownThe role of autophagy in usnic acid-induced toxicity in hepatic cells.
Not available
S-EPMC5729590 | biostudies-literature
UnknownDesign, synthesis and antimicrobial activity of usnic acid derivatives.
Not available
S-EPMC6072497 | biostudies-literature
UnknownInhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility.
Not available
S-EPMC4708991 | biostudies-literature
UnknownTarget identification of usnic acid in bacterial and human cells.
Not available
S-EPMC11221533 | biostudies-literature
TranscriptomicsThe isoxazole derivative of usnic acid induces ER stress response in breast cancer cells that leads to paraptosis-like cell death
This work investigated the molecular mechanisms unterlying the previously reported anticancer activity of the usnic acid isoxazole derivative, named 2b. Using RNA-seq technology transcriptoms of MCF-7 breast cancer cells treated with vehicle or 2b for two diffrent time periods were compared. Among d...
ORGANISM(S): Homo sapiens 
2021-12-23 | GSE191314 | GEO
UnknownEndoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells.
Not available
S-EPMC5736313 | biostudies-literature
UnknownThe novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.
Not available
S-EPMC11362459 | biostudies-literature
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