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ProteomicsUSP13 dictates RAN turnover and vulnerability to ferroptosis in diffused large B cell lymphoma (DLBCL)
To identify the substrates of deubiquitinase USP13, we used a protein label-free quantitation technique, which involves mass spectrometry analysis of peptides from protein digests using liquid chromatography, to identify candidate substrates of USP13 that interact with it from co-immunoprecipitation...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD056804 | Pride
Usp13 Dlbcl Ip-ms 
ProteomicsUSP13 dictates RAN turnover and vulnerability to ferroptosis in diffused large B cell lymphoma (DLBCL)
To identify the substrates of deubiquitinase USP13, we used a protein label-free quantitation technique, which involves mass spectrometry analysis of peptides from protein digests using liquid chromatography, to identify candidate substrates of USP13 that interact with it from co-immunoprecipitation...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD056840 | Pride
Usp13 Dlbcl Ip-ms 
ProteomicsThe deubiquitinase USP13 maintains cancer cell stemness by promoting FASN stability in small cell lung cancer
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13 is highly expressed in SCLC tumor samples and...
ORGANISM(S): Homo Sapiens 
2022-04-06 | PXD032993 |
GenomicsUSP13 Promotes Deubiquitination of ZHX2 and Tumorigenesis in Kidney Cancer
USP13 Promotes Deubiquitination of ZHX2 and Tumorigenesis in Kidney Cancer
PRJNA775640 | ENA
GenomicsUSP13 Drives Lung Squamous Cell Carcinoma via Switching Lung Club Cell Lineage Plasticity
USP13 Drives Lung Squamous Cell Carcinoma via Switching Lung Club Cell Lineage Plasticity
PRJNA1025004 | ENA
TranscriptomicsUSP13 Promotes Deubiquitination of ZHX2 and Tumorigenesis in Kidney Cancer
Clear cell renal cell carcinoma (ccRCC) is characterized by loss of tumor suppressor Von Hippel Lindau (VHL) function. VHL is the component of E3 ligase complex that promotes the ubiquitination and degradation of hypoxia inducible factor alpha (including HIF1alpha and HIF2alpha) and Zinc Fingers And...
ORGANISM(S): Homo sapiens 
2022-07-27 | GSE186717 | GEO
TranscriptomicsUSP13 Drives Lung Squamous Cell Carcinoma via Switching Lung Club Cell Lineage Plasticity
Lung squamous cell carcinoma (LUSC) is associated with high mortality and limited targeted therapies. USP13 is one of the most amplified genes in LUSC, and yet its role in lung cancer is largely unknown. Here, we establish a novel mouse model of LUSC by overexpressing USP13 in KrasG12D/+; Trp53flox/...
ORGANISM(S): Mus musculus 
2024-01-02 | GSE244847 | GEO
UnknownUSP13: Multiple Functions and Target Inhibition.
Not available
S-EPMC9014248 | biostudies-literature
UnknownUSP13 regulates cell senescence through mediating MDM2 stability.
Not available
S-EPMC10807248 | biostudies-literature
UnknownAmplification of USP13 drives ovarian cancer metabolism.
Not available
S-EPMC5133706 | biostudies-literature
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