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GenomicsRNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21
RNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21
PRJNA556041 | ENA
ProteomicsShotgun analysis of proteins in USP21 knock-out and WT HAP-1 cells
Deubiquitinases (DUBs) play a role in regulating protein degradation which is critical for maintaining protein homeostasis. The purpose of this study was to verify biological consequence of genetic depletion of USP21 in human cells on proteome changes and cellular function. Comparison of proteomic a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD044105 | Pride
Cancer progression Atp Mitochondrial respiration Usp21 
ProteomicsTargeted mass spectrometry of Tau preparations purified from Alzheimer’s Disease brains plus either the deubiquitylase USP21 or its activity-dead mutant C221A.
To characterise the abundance of ubiquitylated Tau peptides in the presence of active or inactive variants (wt 196-565 vs. C221A) of the broad spectrum deubiquitylase USP21. Tau peptides are obtained from Tau fibrils purified from post mortem human brains diagnosed with Alzheimer’s. Their detection ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD046645 | Pride
Alzheimer’s disease (de)ubiquitination/ubiquitylation Neurodegeneration 
TranscriptomicsRNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21
USP21 belongs to ubiquitin specific protease (USP) family. To dissect the molecular mechanisms that regulated by USP21 overexpression in PDAC cells, we conducted RNA-seq analysis of iKPC PDAC cells overexpressing wild-type USP21 (WT-USP21) and enzyme dead USP21 (ED-USP21).
ORGANISM(S): Mus musculus 
2019-09-04 | GSE134686 | GEO
GenomicsEffect of USP21 deficiency on transcriptomes in skeletal muscle of mice
Effect of USP21 deficiency on transcriptomes in skeletal muscle of mice
PRJNA669695 | ENA
GenomicsChanges in Treg gene expression upon deletion of Usp22 and Usp21
Changes in Treg gene expression upon deletion of Usp22 and Usp21
PRJNA857304 | ENA
ProteomicsChemBioID - An integrated chemical biology workflow for the analysis of inhibitor induced USP21 target proximity
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-...
ORGANISM(S): Homo sapiens (Human) 
2023-04-25 | PXD041068 | Pride
Usp21 Eubopen Bioid 
GenomicsRNAseq data comparing GFP, wildtype USP21 and enzyme-dead USP21 overexpressing iKPC PDAC cells with KRAS* expression (on dox) and KRAS* extinction (off dox)
RNAseq data comparing GFP, wildtype USP21 and enzyme-dead USP21 overexpressing iKPC PDAC cells with KRAS* expression (on dox) and KRAS* extinction (off dox)
PRJNA741249 | ENA
TranscriptomicsEffect of USP21 deficiency on transcriptomes in skeletal muscle of mice
Skeletal muscle is the pivotal organ for energy homeostasis, but the regulatory mechanisms are largely unknown. Here, we report that ubiquitin specific protease 21 (USP21) is a regulator of skeletal muscle physiology. To elucidate features important for USP21, we performed RNA-sequencing analysis us...
ORGANISM(S): Mus musculus 
2022-01-11 | GSE159558 | GEO
TranscriptomicsRNAseq data comparing GFP, wildtype USP21 and enzyme-dead USP21 overexpressing iKPC PDAC cells with KRAS* expression (on dox) and KRAS* extinction (off dox)
USP21 promotes PDAC tumor cells to bypass KRAS* dependency. To dissect the molecular mechanism, we conducted RNA-seq analysis comparing iKPC cancer cells overexpressing GFP, wildtype USP21 and enzyme-dead USP21 at day 3 after KRAS* extinction. KRAS*-expressing iKPC cells with GFP overexpression are ...
ORGANISM(S): Mus musculus 
2021-09-17 | GSE178860 | GEO
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