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ProteomicsIdentification of USP39 Ligands and Their Application in Targeted Protein Degradation
Alternative splicing is a tightly regulated process essential for transcriptomic and proteomic diversity, and its dysregulation has been implicated in various cancers. Ubiquitin-specific protease 39 (USP39) is a core component of the spliceosome that lacks enzymatic activity, rendering it challengin...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD065738 | Pride
Human Usp39 Protac 
GenomicsRNA sequencing of liver tissues from liver-specific Usp39 knockout (Usp39-HKO) mice
RNA sequencing of liver tissues from liver-specific Usp39 knockout (Usp39-HKO) mice
PRJNA881999 | ENA
ProteomicsComplexome profiling of nuclear lysates from control and USP39-depleted HeLa cells
RNA splicing and protein degradation systems allow the functional adaptation of the proteome in response to changing cellular contexts. However, the regulatory mechanisms connecting these processes remain poorly understood. Here, we show that impaired spliceosome assembly caused by USP39 deficiency ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-25 | PXD050738 | Pride
Hela cells Complexome profiling Usp39 Nucleus Spliceosome 
ProteomicsIdentification of interacting proteins with U4 snRNA with and without USP39
RNA splicing and protein degradation systems allow the functional adaptation of the proteome in response to changing cellular contexts. However, the regulatory mechanisms connecting these processes remain poorly understood. Here, we show that impaired spliceosome assembly caused by USP39 deficiency ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-25 | PXD050688 | Pride
Human U4 snrna Spliceosome Usp39 As oligo pulldown 
GenomicsRNA Immunoprecipitation(RIP)-seq of Flag-USP39 in ovarian cancer cells
RNA Immunoprecipitation(RIP)-seq of Flag-USP39 in ovarian cancer cells
PRJNA661211 | ENA
GenomicsChromatin Immunoprecipitation(ChIP)-seq of Flag-USP39 in ovarian cancer cells
Chromatin Immunoprecipitation(ChIP)-seq of Flag-USP39 in ovarian cancer cells
PRJNA661666 | ENA
TranscriptomicsRNA sequencing of liver tissues from liver-specific Usp39 knockout (Usp39-HKO) mice
Regulation of alternative splicing (AS) is crucial for gene expression and enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Dysregulated AS has been linked to the development of non-alcoholic fatty liver diseases (NAFLD). However, the splicin...
ORGANISM(S): Mus musculus 
2023-09-24 | GSE213633 | GEO
ProteomicsThe spliceosome factor USP39 promotes hepatocellular carcinoma malignancy through regulating mRNA splicing
Abnormal alternative splicing (AS) caused by alterations to splicing factors contributes to tumor progression. Nonetheless, the relevant targets and mechanisms remain elusive in hepatocellular carcinoma (HCC). Here, we reported that overexpression of Ubiquitin-specific protease 39 (USP39), a spliceo...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035928 | Pride
Alternative splicing  kank2  srsf6  hnrnpc  constitutive splicing 
GenomicsRNA sequencing (RNA-SEQ) of USP39 knockdown by shRNA in ovarian cancer cells
RNA sequencing (RNA-SEQ) of USP39 knockdown by shRNA in ovarian cancer cells
PRJNA661066 | ENA
GenomicsThe spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement
The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement
PRJNA726240 | ENA
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