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ProteomicsGFP-CSB and GFP-UVSSA Domain-specific interactors
The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. The function of the TCR proteins CSB, CSA and UVSSA and the manner in which the core DNA repair complex, including transcription fac...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD017329 | Pride
Uvssa Csb Tc-ner 
GenomicsSurvival of cells with deregulated MYC requires UVSSA-dependent regulation of RNAPII dynamics
Survival of cells with deregulated MYC requires UVSSA-dependent regulation of RNAPII dynamics
PRJNA501802 | ENA
UnknownThe UVSSA complex alleviates MYC-driven transcription stress.
Not available
S-EPMC7791342 | biostudies-literature
UnknownTranscription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA.
Not available
S-EPMC10197625 | biostudies-literature
GenomicsSurvival of cells with deregulated MYC requires UVSSA-dependent regulation of RNAPII dynamics
Cancer cells develop strong genetic dependencies enabling survival under oncogenic stress. MYC is a key oncogene activated across most cancers, and identifying associated synthetic lethality can provide important clues about its activity and potential therapeutic strategies. Based on previously cond...
ORGANISM(S): Homo sapiens 
2020-10-28 | GSE121960 | GEO
UnknownUVSSA, UBP12, and RDO2/TFIIS Contribute to Arabidopsis UV Tolerance.
Not available
S-EPMC6492544 | biostudies-literature
UnknownUSP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.
Not available
S-EPMC6927731 | biostudies-literature
GenomicseXcision Repair-sequencing (XR-seq) to map UV induced damage in U2OS cells and in U2OS cells in which CSA or UVSSA genes were knocked out
eXcision Repair-sequencing (XR-seq) to map UV induced damage in U2OS cells and in U2OS cells in which CSA or UVSSA genes were knocked out
PRJNA549258 | ENA
UnknownA C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA.
Not available
S-EPMC4886821 | biostudies-literature
TranscriptomicseXcision Repair-sequencing (XR-seq) to map UV induced damage in U2OS cells and in U2OS cells in which CSA or UVSSA genes were knocked out
We used eXcision Repair-sequencing (XR-seq) to map UV induced damage in U2OS cells and in U2OS cells in which CSA or UVSSA genes were knocked out. Complementation of UVSSA knockout with WT or mutant proteins shows UVSSA is a core component of human transcription coupled repair.
ORGANISM(S): Homo sapiens 
2020-04-13 | GSE132840 | GEO
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