Sort   by:  
 Page size 
ProteomicsRibosome quality control activity potentiates vaccinia virus protein synthesis during infection
Ribosomes are highly abundant cellular machines that perform the essential task of translating the genetic code into proteins. Cellular translation activity is finely tuned and proteostasis insults, such as those incurred upon viral infection, activate stress signaling pathways that result in transl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Vaccinia Virus Wr (ncbitaxon:10254) 
2021-01-05 | MSV000086660 | MassIVE
TranscriptomicsDiversity in the polyadenylation and decay of human cellular microRNAs during Vaccinia virus infection
Vaccinia virus (VACV) is a large cytoplasmic dsDNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. Here we use small RNA sequencing to comprehensively quantify the impact of VACV infection on the expression of endogenous small non-coding RNAs (sncRNAs)...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-54235 | biostudies-arrayexpress
TranscriptomicsStunned silence: gene expression programs in human cells infected with Monkeypox or Vaccinia virus
Three experiments, corresponding to the three figures in the article, are represented in this set. Each experiment was an ex vivo treatment time course as described in the paper. For each of the experiments, mRNA was isolated at the indicated time points, cDNA was directly prepared by reverse transc...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-24125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse with human solid tumors eradicated with an intravenously injected light-emitting oncolytic Vaccinia virus
Previously we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new recombinant VACV, GLV-1h68, as a simultaneous diagnostic and therapeutic agent, was constructed by inserting three expressio...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8513 | biostudies-arrayexpress
TranscriptomicsPermissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. This therapy relies on efficient replication of virus in tumor cells in vivo with minimal or no replication in normal tissues. We recently described GLV-1h68 as a modified Vaccinia Virus (VACV) constr...
ORGANISM(S): Homo sapiens 
2012-03-24 | E-GEOD-28472 | biostudies-arrayexpress
ProteomicsMonkeypox and vaccinia virus infection of primary human astrocytes
Primary human astrocytes were infected with either monkeypox virus (MPXV clade IIb lineage), vaccinia virus (VACV: Acambis 2000), or controls (MC=monkeypox control, AC = Vaccinia control) at an MOI of 10 for 6 h. Samples (n=4) were analyzed by LC-MS/MS with label-free quantification where the data w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-21 | MSV000092229 | MassIVE
GenomicsCascade evolution in poxviruses: retrotransposon-mediated host gene capture, complementation and recombination
Examination of partially purified virus populations that had horizontally acquired mCherry-E3L during infection, and longitudinal analysis of serially-passaged viruses that had acquired mCherry-E3L in an essential vaccinia virus gene.
ORGANISM(S): Vaccinia virus Lister 
2022-09-22 | E-MTAB-9682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hela cells infected with Vaccinia mutants
Samples were received from the lab of Bertram Jacobs, experiments done by Jeff Langland (langland@asu.edu). Midlog Hela cells were infected with copenhagen strain Vaccinia Virus at MOI of 5. Viral stocks were sucrose pad purified. Incubated 2, 6, and 9 hrs post infection. viral mutants include VC2 (...
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-64 | biostudies-arrayexpress
ProteomicsNon-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia VirusNon-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia VirusNon-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia VirusV
Vaccinia virus is a large enveloped DNA virus, which, like all poxviruses, replicates in the cytoplasm of infected cells. Vaccinia was historically thought to encode all the proteins required for its replication. However, recent findings have shown that nuclear host proteins are redirected to the cy...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD060689 | Pride
Topoisomerase 2 Replication Vaccinia Lc-ms/ms 
TranscriptomicsRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Transcription profiling of mouse CD4+ and CD8+ T cells extracted from GFP-Egr2 knockin (Egr2 Kin) and hCD2-Cre / Egr2loxP/loxP / Egr3-/- Egr2/3 DKO) mice 7 days after infection with vaccinia virus.
ORGANISM(S): Mus musculus 
2017-06-30 | E-MTAB-5338 | biostudies-arrayexpress
Sort   by:  
 Page size