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UnknownUncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease.
Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer's disease...
S-EPMC11906971 | biostudies-literature
UnknownResting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.
Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, ...
S-EPMC10170147 | biostudies-literature
UnknownAmyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.

Background

Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined...
S-EPMC7415608 | biostudies-literature
UnknownAssessment of white matter hyperintensity severity using multimodal magnetic resonance imaging.
White matter hyperintensities are radiological abnormalities reflecting cerebrovascular dysfunction detectable using MRI. White matter hyperintensities are often present in individuals at the later stages of the lifespan and in prodromal stages in the Alzheimer's disease spectrum. Tissue alterations...
S-EPMC10636521 | biostudies-literature
UnknownThe neurophysiological brain-fingerprint of Parkinson's disease.

Background

Research in healthy young adults shows that characteristic patterns of brain activity define individual "brain-fingerprints" that are unique to each person. However, variability in these brain-fingerprints increases in individuals with neurological conditions, challenging the clin...
S-EPMC11253223 | biostudies-literature
UnknownAssociation of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.

Importance

National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD).

Objective

To assess the clinical value of these biological criteria to identify older...
S-EPMC9339146 | biostudies-literature
UnknownAccelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI da...
S-EPMC8429427 | biostudies-literature
UnknownAssociations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease.
Parkinson's disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. Although SN dopamine dysfunction has clear neurophysiological effects, the ...
S-EPMC11884654 | biostudies-literature
UnknownSpatial Extent of Amyloid-β Levels and Associations With Tau-PET and Cognition.

Importance

Preventive trials of anti-amyloid agents might preferably recruit persons showing earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET).

Objective

To investigate the timing at which Aβ-PET binding starts showing associations with other ...
S-EPMC9396472 | biostudies-literature
UnknownFrequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity.

Importance

Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD).

Objective

To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes.

Desig...

S-EPMC12848857 | biostudies-literature
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