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TranscriptomicsTranscription profiling of human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1)
Human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1).
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2049 | biostudies-arrayexpress
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
UnknownIdentification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.
Not available
S-EPMC3595425 | biostudies-literature
TranscriptomicsRetroviral Integration Mutagenesis in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression as a Prognostic Indicator
Acute myeloid leukemia (AML) results from multiple genetic and epigenetic aberrations, many of which remain unidentified. Frequent loss of large chromosomal regions marks haplo-insufficiency as one of the major mechanisms contributing to leukemogenesis. However, which haplo-insufficient genes (HIGs)...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-19706 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-181 target genes and a common prognostic gene signature in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30258 | biostudies-arrayexpress
TranscriptomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35856 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CEBPA double-, single-mutant and CEBPA wild type AML
A previously predictive CEBPA double mutant (CEBPAdm) signature was hampered by the recently reported CEBPA silenced AML cases that carry a similar gene expression profile (GEP). Two independent AML cohorts were used to train and evaluate the predictive value of the CEBPAdm signature in terms of sen...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-22845 | biostudies-arrayexpress
TranscriptomicsIdentification of prognostic gene signatures in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30285 | biostudies-arrayexpress
GenomicsBase-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in Acute Myeloid Leukemia
Here we used Illumina NGS for high-throughput profiling of the DNA methylome in two human colon cancer derived cell lines, two human normal bone marrow CD34+ controls and in five human Acutre Myeloid Leukeima patient samples. These data can be used to determine the CpG cytosine methylation pattern ...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-37454 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in granulopoiesis
Normal human neutrophil development is a complex biological process, where the balance between cell proliferation, differentiation and apoptosis is tightly regulated by a transcriptional program that results in the production of appropriate numbers of circulating mature neutrophils. MicroRNAs (miRNA...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-GEOD-21437 | biostudies-arrayexpress
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