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Effect of ablation of SAP102 or PSD-95 genes in mice compared to wild-types littermates
ORGANISM(S): Mus musculus 
We compare here the neurodegenerative processes observed in the hippocampus of bitransgenic mice with chronically altered levels of cAMP-response element-binding protein (CREB) function. The combination of genome-wide transcriptional profiling of degenerating hippocampal tissue with microscopy analy...
ORGANISM(S): Mus musculus 
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
Effect of different chemical stimuli (NMDA(N-methyl-D-aspartic acid), forskolin/rolipram/0 Mg, bicuculline) on gene expression after 1 h of stimulation in hippocampal slices
ORGANISM(S): Mus musculus 
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration in animal models for different neuropsychiatric conditions. However, the impact of these drugs on hippocampal histone acety...
ORGANISM(S): Mus musculus 
The epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CBP, a histone acetyltransferase involved in mental retardation, in the genesis and maintenance of long-lasting systemic and behavioral adaptations to e...
ORGANISM(S): Mus musculus 
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
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