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ProteomicsStructural elucidation of a novel mechanism for bacteriophage-based inhibition of the RNA degradosome
In all domains of life, the catalysed degradation of RNA facilitates rapid adaption to changing environmental conditions. We identified a virus-encoded protein that directly binds and inhibits the RNA degradation machinery of its bacterial host, allowing efficient accumulation of viral RNA in the in...
ORGANISM(S): Escherichia coli 
2016-07-27 | PXD003285 | Pride
Escherichia coli Protein-rna interactions Rna degradosome X-ray crystallography Φkz Protein-protein interactions Pseudomonas aeruginosa Phage 
MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
TranscriptomicsFS001: Aberrant gene expression in dogs with portosystemic shunts
Background: Congenital portosystemic shunts are developmental anomalies of the vascular system that cause portal blood to bypass the liver. Large-breed dogs are reported to have a predisposition for intrahepatic portosystemic shunts (IHPSS) and small-breed dogs a predisposition for extrahepatic port...
ORGANISM(S): Canis lupus familiaris 
2013-03-01 | E-GEOD-39005 | biostudies-arrayexpress
ProteomicsUnraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model
Pseudomonas aeruginosa chronically infects the lungs of people with cystic fibrosis (pwCF), where it produces a broad range of proteases that impact host immunity and inflammation. While some studies suggest these enzymes induce inflammation and may contribute to the excessive inflammatory response ...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2025-10-23 | PXD065321 | Pride
Cystic fibrosis Proteomics Inflammation Elastase b Pseudomonas aeruginosa Bacterial proteases Virulence factors 
UnknownMolecular basis for anti-jumbo phage immunity by AVAST type 5.
Not available
S-EPMC12931631 | biostudies-literature
UnknownBacterial Interference With Lactate Dehydrogenase Assay Leads to an Underestimation of Cytotoxicity.
Not available
S-EPMC7523407 | biostudies-literature
UnknownAn integrated toolbox to profile macrophage immunometabolism.
Not available
S-EPMC9046227 | biostudies-literature
UnknownOncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment.
Not available
S-EPMC6176807 | biostudies-literature
UnknownUnified Synthesis Platform for 1,2,3-Trisubstituted Cyclopentadienyl Ligands Decouples Sterics from Electronics.
Not available
S-EPMC12856903 | biostudies-literature
UnknownItaconate promotes a wound resolving phenotype in pro-inflammatory macrophages.
Not available
S-EPMC9800195 | biostudies-literature
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