Sort   by:  
 Page size 
MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
MetabolomicsGenome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in NAFLD by integrating global transcriptomic data, from human liver biopsies, and metabolic flux data, measured across the ...
2016-12-15 | MTBLS298 | MetaboLights
TranscriptomicsGene Expression Profiles of CD21low B cells in Common Variable Immunodeficiency
The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population c...
ORGANISM(S): Homo sapiens 
2009-07-30 | E-GEOD-17269 | biostudies-arrayexpress
TranscriptomicsMapping of variable DNA methylation across multiple cell types defines a dynamic regulatory landscape of the human genome
DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation and cancer at a genome-wide scale. Our understanding of genome-wide DNA methylation changes...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-69894 | biostudies-arrayexpress
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations
This SuperSeries is composed of the following subset Series: GSE27125: Genome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [mRNA profiling] GSE27199: Genome-wide consequences of compromised NMD and their relavence for varia...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27433 | biostudies-arrayexpress
TranscriptomicsIdentification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ~50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-56606 | biostudies-arrayexpress
TranscriptomicsStaphVar-DNA microarray analysis of accessory genome of community-acquired methicillin resistant Staphylococcus aureus
Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed...
ORGANISM(S): Staphylococcus aureus 
2009-02-14 | E-GEOD-13702 | biostudies-arrayexpress
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
GenomicsWhole-exome sequencing of Common Variable Immunodeficiency
An investigation of rare genetic variants in patients presenting with Common Variable Immunodeficiency
ORGANISM(S): Homo Sapiens 
2022-04-11 | PRJEB52220 | EVA
UnknownThe Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation.
Not available
S-EPMC1088291 | biostudies-literature
Sort   by:  
 Page size