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TranscriptomicsP. falciparum Complicated Malaria: Modulation and Connectivity between Exportome and Variant Surface Gene Families
In temperate and sub-tropical regions of Latin America, complicated malaria manifested as hepatic dysfunction or renal dysfunction is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated malaria in children, much less is...
ORGANISM(S): Plasmodium falciparum 
2015-07-07 | E-GEOD-59844 | biostudies-arrayexpress
ProteomicsVariant Surface Glycoprotein expression in the Trypanosoma vivax genome C4PR_LIV
Trypanosoma vivax causes animal trypanosomiasis across Africa and South America. An accurate genome sequence is essential to functional genetics and the design of novel diagnostics, drugs and vaccines. Our aim is to improve the existing T. vivax Y486 reference genome assembly to understand the basis...
ORGANISM(S): Trypanosoma vivax (strain Y486) 
2026-10-15 | PXD075690 | Pride
Variant surface glycoprotein 
TranscriptomicsUstilago maydis gene expression after growth on hydrophobic surface plus/minus hydroxy fatty acids
Infection-related development of phytopathogenic fungi is initiated by sensing and responding to plant surface cues. This response results in the formation of specialized infection structures, so-called appressoria. To unravel the program inducing appressoria in the biotrophic smut fungus Ustilago m...
ORGANISM(S): Ustilago maydis 
2014-07-23 | E-GEOD-53947 | biostudies-arrayexpress
ProteomicsTbSAP is a novel chromatin protein repressing metacyclic Variant Surface Glycoprotein expression sites in bloodstream form Trypanosoma brucei
The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective Variant Surface Glycoprotein (VSG) coat for survival in the mammalian host. A single trypanosome has >2000 VSG genes and pseudogenes of which only one is expressed from one of ~15 telomeric bloodstre...
ORGANISM(S): Trypanosoma brucei 
2020-11-06 | PXD022397 | Pride
Lc/ms-ms 
GenomicsVirulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein
The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or negatively, including a key ESX-1 component, th...
ORGANISM(S): Mycobacterium tuberculosis 
2012-04-02 | E-GEOD-35149 | biostudies-arrayexpress
TranscriptomicsProteomic view of the Plasmodium falciparum life cycle
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of t...
ORGANISM(S): Plasmodium falciparum 3D7 
2002-12-22 | E-GEOD-92 | biostudies-arrayexpress
GenomicsTbSAP is a novel chromatin protein repressing metacyclic Variant Surface Glycoprotein expression sites in bloodstream form Trypanosoma brucei
TbSAP is a novel chromatin protein repressing metacyclic Variant Surface Glycoprotein expression sites in bloodstream form Trypanosoma brucei
PRJNA674063 | ENA
ProteomicsIn Depth Characterization of Protein N-Glycosylation for a COVID-19 Variant-Design Vaccine Spike Protein
In this work, we performed comprehensive glycosylation analysis to a candidate vaccine Spike protein. The Spike protein studied here was featured by a set of structural designs such as the six-proline substitution, furin cleavage site replacement, trimeric foldon incorporation as well as “hotspots” ...
ORGANISM(S): Cricetulus Griseus 
2022-11-19 | PXD038220 |
ProteomicsThe trypanosome Variant Surface Glycoprotein mRNA is stabilized by an essential unconventional RNA-binding protein
Salivarian trypanosomes cause human sleeping sickness and economically important livestock diseases, transmitted by Tsetse flies and replicating extracellularly throughout the life cycle. The surface of "bloodstream forms", which live within mammals, is coated by a monolayer of a Variant Surface Gly...
ORGANISM(S): Trypanosoma brucei 
2021-04-14 | PXD021772 | Pride
Bloodstream forms Vsg Trypanosomes 
ProteomicsProteomic profiling reveals the impact of surface functionalization on the protein corona formed on superparamagnetic iron oxide nanoparticles
The protein corona formed on the surface of nanomaterials is critical to understanding their biological behavior, as it is regulated by both the physicochemical properties of the nanomaterials and the physiological environment. The interplay between material synthesis characteristics, protein corona...
ORGANISM(S): Homo Sapiens 
PXD056769 |
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