Vascular dementia

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CHEBI:144256 (1)
CHEBI:144239 (1)

Metabolite Name

2-Hydroxyisocaproic Acid (2)
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Lab affiliation

Basic Medicine, Guangxi University of Chinese Medicine, Nanning, China (1)
Brock University (1)
Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (1)
Department of Biomedical Sciences, Jepps group, University of Copenhagen, Denmark (lab head) (1)
Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia. (1)
Departments of Neurology, University of Michigan, Ann Arbor, MI 48109-5622, USA. Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-5622, USA Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA (1)
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany (1)
Nanyang Technological University (1)
Professor, Diana Davis Spencer Foundation Chair for Glaucoma Research, The Jackson Laboratory (1)
Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France (1)
UK Dementia Research Institute, University of Edinburgh (1)
Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig-Maximilians-University (LMU) Munich, Germany. (1)
second xiangya hospital central south university (1)

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Multi-omics reveals the protective mechanisms of Gastrodia elata ethyl acetate extract in vascular dementia

Objective: This study aimed to investigate the ameliorative effect of the ethyl acetate extract of Gastrodia elata (EEGE) on vascular dementia (VD) and its underlying mechanisms.

Methods: A VD rat model was established using the two-vessel occlusion method, while an in vitro cerebral ...

2026-01-15 | MTBLS13695 | MetaboLights

Intermittent Fasting Reprograms the Brain Proteome to Prevent Synaptic Degeneration and Cognitive Impairment in Vascular Dementia

Vascular dementia (VaD), driven by chronic cerebral hypoperfusion (CCH), leads to synaptic degeneration and cognitive decline, yet mechanisms linking vascular dysfunction to synaptic loss remain unclear. Intermittent fasting (IF) has emerged as a potential intervention, but its effects on synaptic i...

ORGANISM(S): Mus musculus (Mouse)

2025-09-08 | PXD064537 | Pride

Label-Free LC-MS/MS Proteomic Analysis of Urinary Identification in Diabetic Vascular Dementia

Objective: The aim of this study was to identify novel diagnostic biomarkers of diabetic vascular dementia (DVD) and unraveling the underlying mechanisms using mass spectrometry (MS). Methods: Label-Free LC-MS/MS proteomics analysis was applied to urine samples from four groups including 14 vascular...

ORGANISM(S): Homo sapiens (Human)

2021-01-14 | PXD022189 | Pride

Urine proteomics Protein Vascular dementia Biomarkers Diabetes

snRNAseq of human vascular dementia white matter vs control

PRJNA882878 | ENA

Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review.

Not available

S-EPMC11851133 | biostudies-literature

Indianapolis-Ibadan, Nigeria Comparative Epidemiological Study of Dementia

In 1991 collaboration between researchers at Indiana University School of Medicine and the University of Ibadan, Ibadan, Nigeria established the Indianapolis-Ibadan Dementia Project. It is a longitudinal, prospective population-based comparative epidemiological study of the prevalence and inciden...

phs000378 | dbGaP

1.Integrated network pharmacology and proteomics to reveal the cognitive improvement effect of Wuzang Wenyang Huayu decoction on vascular dementia

To investigate the Wuzang Wenyang Huayu Decoction Regulates Differentially Expressed Proteins in the Rat, Hippocampus after Cerebral Hypoperfusion.

ORGANISM(S): Rattus norvegicus (Rat)

2023-03-11 | PXD028968 | Pride

Dementia Hippocampus Rats

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study.

Not available

S-EPMC6390174 | biostudies-literature

Expression data from post mortem Alzheimer's disease brains

To identify molecular pathological alterations in AD brains, we performed interspecies comparative microarray analyses using RNAs prepared from postmortem human brain tissues donated for the Hisayama study and hippocampal RNAs from the triple-transgenic mouse model of AD (3xTg-AD) Three-way ANOVA of...

ORGANISM(S): Homo sapiens

2013-04-17 | E-GEOD-36980 | biostudies-arrayexpress

Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia [snRNA-Seq]

PRJNA1187215 | ENA

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