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Albeit vascular prostheses for the replacement of large arteries (e.g. aorta) are commercially available for decades, small-diameter vascular grafts (e.g., for coronary artery bypass graft surgery) still remain an unmet clinical need. Biostable polymers commonly used for the fabrication of aortic pr...
ORGANISM(S): Ovis aries 
2022-11-26 | PXD036520 | Pride
Spatial transcriptomic profiling of Patient and Patient-corrected bioengineered vascular grafts.
Investigate the effect of recombinant human IL-17A on vascular smooth muscle cells cultured from human aortas. Experiment Overall Design: SMCs from the aortas of three different donors were cultured in M199 media supplemented with 20% FCS and used at passage 3. The cells were either not treated or t...
ORGANISM(S): Homo sapiens 
Generation of abundant engraftable hematopoietic cells from autologous tissues promises new therapies for hematologic diseases. Differentiation of pluripotent stem cells into hematopoietic cells results in emergence of cells that have poor engraftment potential. To circumvent this hurdle, we have d...
ORGANISM(S): Homo sapiens 
Spatial transcriptomic profiling of two replicates of Patient and two replicates of Patient-corrected bioengineered vascular grafts harvested at week 8 post-implantation.
ORGANISM(S): Homo sapiens 
2024-05-08 | GSE216992 | GEO
Immune-mediated regeneration of cell-free vascular grafts in an ovine model
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