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TranscriptomicsThe non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs
Vault particles are conserved organelles that have been implicated in multidrug resistance and intracellular transport. They are formed by three different proteins and the non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from th...
ORGANISM(S): Homo sapiens 
2009-09-07 | E-GEOD-16060 | biostudies-arrayexpress
UnknownThe trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA.
Not available
S-EPMC12547018 | biostudies-literature
UnknownThe Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.
Not available
S-EPMC2193651 | biostudies-literature
ProteomicsThe vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using cryo-electron tomography of Dictyostelium discoideum cells, we define the distribution, structural s...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2026-04-21 | PXD071329 | Pride
ProteomicsExploring the vault interactome in the divergent eukaryote Trypanosoma brucei
Many, but not all Eukaryotes have protein-enclosed compartments called vaults. Vaults are composed of multiple copies of the major vault protein (MVP), symmetrically assembled into a basket like shell. Whilst there is some evidence that these compartments are engaging in mRNA maturation and intrigui...
ORGANISM(S): Trypanosoma brucei 
2024-12-12 | PXD056004 | Pride
Trypanosoma Affinity isolation Major vault protein Cryomilling Bioid Vault particle 
GenomicsThe non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs
Vault particles are conserved organelles that have been implicated in multidrug resistance and intracellular transport. They are formed by three different proteins and the non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from th...
ORGANISM(S): Homo sapiens 
2009-09-08 | GSE16060 | GEO
UnknownAssessment of Vault Particles in Cancer Cell Line-Derived Extracellular Vesicle Preparations.
Not available
S-EPMC12326185 | biostudies-literature
UnknownThe 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.
Not available
S-EPMC2169495 | biostudies-literature
UnknownThe mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.
Not available
S-EPMC2752026 | biostudies-literature
UnknownVault RNAs (vtRNAs): Rediscovered non-coding RNAs with diverse physiological and pathological activities.
Not available
S-EPMC10491885 | biostudies-literature
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