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TranscriptomicsGenome-wide analysis of gene expression in VAV1-/- versus VAV1+/+ bone marrow (BM)-macrophages
Analysis of differential gene expression profiles in VAV1-/- versus VAV+/+ BM-macrophages , respectively. A distinct expression profile in VAV1-/- versus VAV1+/+ (wild-type) BM-macrophages allows to resolve molecular mechanisms. Total RNA was obtained froms BM-macrophages of VAV1+/+ and VAV1-/- mic...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-36123 | biostudies-arrayexpress
ProteomicsVav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28 in CD3-stimulated T cells
Vav1, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T cell receptor (TCR) signaling cascade, is rapidly tyrosine phosphorylated in response to T cell activation. Previous studies using Vav1 knockout models have demonstrated its importance in TCR signaling. Although Vav...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD002022 | Pride
T cell receptor Tyrosine phosphorylaiton Vav1 
TranscriptomicsGenome-wide analysis of gene expression in VAV1-/- versus VAV1+/+ bone marrow (BM)-macrophages
Analysis of differential gene expression profiles in VAV1-/- versus VAV+/+ BM-macrophages , respectively. A distinct expression profile in VAV1-/- versus VAV1+/+ (wild-type) BM-macrophages allows to resolve molecular mechanisms.
ORGANISM(S): Mus musculus 
2013-03-08 | GSE36123 | GEO
ProteomicsAnalysis of the Vav1 interactome in primary T cells
In this study, we combined mouse genetics and quantitative proteomics to characterize in a comprehensive manner the VAV1 interactome. A line of knock-in mouse expressing endogenous VAV1 molecules with a genetic tag permitting affinity purification was generated and combined with affinity purificatio...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-26 | PXD004217 | Pride
Ap-ms Primary t cell Tcr Vav1 Interactome Signalosome 
TranscriptomicsEXPRESSION OF VAV1 IN GLIOBLASTOMA MULTIFORME
Background: Even though much progress has been made in the understanding of the molecular nature of glioma, the survival rates of patients affected of this tumour have not changed significantly during these years. Thus, a deeper understanding of this malignancy is still needed in order to predict it...
ORGANISM(S): Homo sapiens 
2010-09-30 | GSE24072 | GEO
GenomicsCancer-associated mutations in VAV1 trigger variegated signaling outputs and drive T cell lymphomagenesis
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and drive T cell lymphomagenesis
PRJNA692770 | ENA
UnknownVav1 Promotes B-Cell Lymphoma Development.
Not available
S-EPMC8946024 | biostudies-literature
GenomicsCharacterization of the spectrum of trivalent VAV1 mutation-driven tumors using a gene-edited mouse model
Characterization of the spectrum of trivalent VAV1 mutation-driven tumors using a gene-edited mouse model
PRJNA781998 | ENA
UnknownVav1 as a central regulator of invadopodia assembly.
Not available
S-EPMC3917499 | biostudies-literature
UnknownEstrogen induces Vav1 expression in human breast cancer cells.
Not available
S-EPMC4048212 | biostudies-literature
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