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TranscriptomicsThe effect of ERG overexpression and ERG knockdown by shRNA in RWPE1 and VCAP cells, respectively
The goal of this project was to analyze the global gene expression profiles of RWPE1 and VCAP cells following transfection of GFP, GFP-ERG at 48 and 72hrs time points and stable ERG shRNA, scramble shRNA, respectively. RWPE1 cells were transfected with GFP or GFP-ERG. VCAP cells were transfected wit...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-16671 | biostudies-arrayexpress
TranscriptomicsClorgyline treatment of VCaP cells
Purpose: Monoamine oxidase A (MAOA) is a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine. Its inhibitors are commonly used to treat neurologic conditions including depression. Recently, we and others identified high expression of MAOA in normal basal pro...
ORGANISM(S): Homo sapiens 
2010-10-25 | E-GEOD-19822 | biostudies-arrayexpress
ProteomicslncRNA IGF1R-AS1 protein interactome in VCaP cells
This project aims to idetify the proteins that interact with lncRNA IGF1R-AS1 in a prostate cancer cell line, VCaP cells, through LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-02-10 | PXD074272 | Pride
Lc-ms Vcap Igf1r-as1 
TranscriptomicsExpression profiling of human prostate VCaP and LNCaP cancer cells after silencing ERG or ETV1, respectively
Chromosomal rearrangements involving ETS factors, ERG and ETV1, occur frequently in prostate cancer. We here examine human prostate cancer cells control VCaP and LNCaP cells with ERG- or ETV1-silenced VCaP or LNCaP cells, respectively, in hormone deprived and stimulated conditions. VCAP and LNCaP ce...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-39354 | biostudies-arrayexpress
TranscriptomicsAndrogen stimulation time-course of TMPRSS2-ERG fusion positive VCaP cells.
The TMPRSS2-ERG fusion positive prostate cancer cell line VCaP was grown for 72h in steroid depleted media (RPMI 10% CDT FBS) prior to vehicle (ethanol) or androgen stimulation (1nM R1881). To allow detailed analysis of androgen regulated gene expression in the VCaP prostate cancer cell line total ...
ORGANISM(S): Homo sapiens 
2014-12-31 | E-MTAB-2968 | biostudies-arrayexpress
TranscriptomicsStable over expression of the SPOP-substrate ZMYND11 in VCaP cells
SPOP is known to bind to serine/theronine-rich degrons on substrate proteins. We identified two degron sequences within the PWWP and MYND domain of ZMYND11, a novel SPOP substrate, and investigated whether ZMYND11 may contribute to the transcriptional output of mutant SPOP in VCaP cancer cells. Henc...
ORGANISM(S): Homo sapiens 
2020-12-16 | E-MTAB-7173 | biostudies-arrayexpress
GenomicsIdentification of ZMYND11 binding sites in VCaP cells with stable overexpression of either mutant (Y87C) or wild-type SPOP.
SPOP is known to bind to serine/theronine-rich degrons on substrate proteins. We identified two degron sequences within the PWWP and MYND domain of ZMYND11, a novel SPOP substrate, and investigated whether ZMYND11 may contribute to the transcriptional output of mutant SPOP in VCaP cancer cells. We m...
ORGANISM(S): Homo sapiens 
2020-12-05 | E-MTAB-7174 | biostudies-arrayexpress
GenomicsHNF1B VCaP ChIP-seq
ChIP-seq data for HNF1B VCaP and input.
PRJEB46087 | ENA
GenomicsH3K4me1 and H3K27ac in Vcap cells
H3K4me1 and H3K27ac in Vcap cells
PRJNA956498 | ENA
GenomicsGenome-wide mapping of retinoblastoma (Rb) binding sites in prostate cancer cell lines VCaP and LNCaP
Although well characterized as a transcriptional activator, androgen receptor (AR) can also function as a direct transcriptional repressor in prostate cancer cells. The major targets of the AR repressive function are genes mediating DNA synthesis. In this study, we found that AR was recruited to th...
ORGANISM(S): Homo sapiens 
2015-12-19 | E-GEOD-76141 | biostudies-arrayexpress
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