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MetabolomicsMaternal lipid mobilization is essential for embryonic development in a key malaria vector
Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we ...
2024-11-05 | MTBLS9881 | MetaboLights
TranscriptomicsPreadaptation of Yersinia pestis to resist mammalian innate immunity during transit through the flea vector
Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37°C induces many known virulence factors...
ORGANISM(S): Yersinia pestis 
2010-04-06 | E-GEOD-16493 | biostudies-arrayexpress
GenomicsVector
Vector Targeted Locus (Loci)
PRJNA315083 | ENA
TranscriptomicsTranscriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set2]
We use RNA-Seq to explore the reaction norm of gene expression of larval Anopheles coluzzii and An. merus to a gradient of salinity. After rearing in freshwater, separate pools of 18 h post-hatch larval instars of An. merus and An. coluzzii were briefly (6 h) exposed to one of six water salinities: ...
ORGANISM(S): Anopheles merus 
2016-03-09 | E-GEOD-74819 | biostudies-arrayexpress
TranscriptomicsTranscriptomic differences between euryhaline and stenohaline malaria vector sibling species in response to salinity stress [set1]
We use RNA-Seq to investigate gene expression differences in response to saltwater exposure by the larval stages of the obligate freshwater mosquito Anopheles coluzzii (formerly An. gambiae "M" form), and the euryhaline An. merus. After rearing in freshwater, both young and old larval inst...
ORGANISM(S): Anopheles merus 
2016-03-09 | E-GEOD-59632 | biostudies-arrayexpress
Genomicsmamelian expression vector
mamelian expression vector
PRJNA362702 | ENA
GenomicsPlasmid vector pSP189
Plasmid vector pSP189 Genome sequencing
PRJNA302825 | ENA
TranscriptomicsHMLER cells expressing either FOXC2 or a vector control
We used microarrays to investigate the transcription profile of FOXC2 expression in a human mammary epithelial cell line. HMLER cells were infected with either a control vector or a retroviral vector expressing FOXC2.
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44335 | biostudies-arrayexpress
ProteomicsPredictive chemoproteomics and functional validation reveal Coeae6g mediated insecticide cross-resistance in the malaria vector Anopheles gambiae
This project investigates insecticide resistance mechanisms in Anopheles gambiae using Activity-Based Protein Profiling (ABPP). By targeting serine hydrolases (SHs) with fluorophosphonate (FP) probes and mass spectrometry, we identified COEAE6G as a key enzyme conferring resistance to Pirimiphos-met...
ORGANISM(S): Anopheles gambiae str. PEST 
2025-10-17 | PXD060698 | Pride
Resistance Anopheles gambiae Pirimiphos-methyl Abpp 
ProteomicsComparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines
Vector-based SARS-CoV-2 vaccines such as AstraZeneca's ChAdOx1 nCoV-19 have been associated with vaccine-induced thrombosis (TTS/VITT). We studied ChAdOx1 nCov-19 (AstraZeneca) and Ad26.COV2.S (Johnson & Johnson) and compared the vaccines using proteomics with mass spectrometric measurements. We cou...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD027344 | Pride
Ad26.cov2.s Sars-cov-2 Vector vaccines Chadox1 
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