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TranscriptomicsTranscriptome sequencing to identify transcription factor regulatory network and alternative splicing in endothelial cells under VEGF stimulation
Human umbilical vein vascular endothelial cells (HUVECs) are crucial for angiogenesis that benefits functional recovery after cerebral infarction. This study aims to investigate the mechanisms underlying the effects of vascular endothelial growth factor (VEGF) on HUVECs. HUVECs were treated with 16 ...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71216 | biostudies-arrayexpress
ProteomicsVEGF orchestration of the p130Cas Interactome
p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEG...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080860 | MassIVE
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with VEGF-A
Angiogenesis, the formation of new capillaries by sprouting from preexisting vessels, is mainly induced by VEGF-A. To identify genes which are induced by VEGF-A in endothelial cells, HUVEC were starved and induced by VEGF-A165 for 30, 60 and 150min. RNA of induced and uninduced cells was isolated an...
ORGANISM(S): Homo sapiens 
2009-10-20 | E-GEOD-15464 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of pancreatic islets and islet-derived macrophages and endothelial cells modulated by vascular endothelial growth factor-A signaling
Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular endothelial growth factor-A (VEGF-A) signaling are important for islet endocrine cell differentiation and the formation of highly vascularized islets. To dissect how VEGF-A signaling modulates intra-islet vas...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-72546 | biostudies-arrayexpress
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
ProteomicsKT01: The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis
The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis
ORGANISM(S): Bartonella Henselae Str. Houston-1 
2020-06-10 | PXD017507 | JPOST Repository
ProteomicsKT01_b: The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis. Wild type.
The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis. Wild type.
ORGANISM(S): Bartonella Henselae Str. Houston-1 
2020-06-10 | PXD018354 | JPOST Repository
TranscriptomicsSlit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle by inducing capillary sprouting and decreasing vascular permeability via reduced eNOS activity
Rationale: Slit2 is a possible modulator of vascular endothelial growth factor (VEGF) - induced angiogenesis, but its effects have not been tested in large animal models. Objective: We studied the effect of Slit2 on therapeutic angiogenesis induced by VEGF receptor 2 (VEGFR2) ligands Vammin and VEGF...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-63283 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat aortic rings treated with angiopoietin-1, VEGF or untreated
Specific Aims ; To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after e...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3355 | biostudies-arrayexpress
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