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ProteomicsProteomic profiling of tendon-specific VHL knockout and VHL-dependent double knockout mouse tail tendon fascicles
This study investigates how chronic activation of HIF1α in tendon cells drives pathological extracellular matrix (ECM) remodeling and whether these changes can be modulated by genetic rescue strategies. Using tendon cell-specific deletion of Vhl (Scx;Vhl) in mice, which stabilizes HIF1α, we observed...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-24 | PXD069135 | Pride
Lc-msms Vegfa ko Mouse Hif1a ko Tendon Vhl ko 
TranscriptomicsCortical astrocytic neogenin, a key protein switching HIF1/2ɑ-VEGFa-induced angiogenesis to MEGF10-driven phagocytosis
Astrocytes play key roles in multi-cellular processes in the brain, including maintaining homeostasis of blood vessels (BVs) and clearance of damaged cell debris. The detailed underlying mechanisms remain elusive. Here, we provide evidence that cortical astrocytic neogenin (NEO1) coordinates MEGF10-...
ORGANISM(S): Mus musculus 
2026-01-31 | GSE311122 | GEO
TranscriptomicsATF4 governs functional expansion of hematopoietic stem cells partially via Angptl3 in the fetal liver microenvironment (RNA-Seq)
In this study, we demonstrated that deletion of the activating transcription factor 4 (ATF4) resulted in severely impaired HSC expansion in the fetal liver at E12.5 and E15.5. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region at E11.5 was not significantly aff...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-66380 | biostudies-arrayexpress
GenomicsCortical astrocytic neogenin, a key protein switching HIF1/2ɑ-VEGFa-induced angiogenesis to MEGF10-driven phagocytosis
Cortical astrocytic neogenin, a key protein switching HIF1/2ɑ-VEGFa-induced angiogenesis to MEGF10-driven phagocytosis
PRJNA1368708 | ENA
UnknownERp44 is required for endocardial cushion development by regulating VEGFA secretion in myocardium.
Not available
S-EPMC8891561 | biostudies-literature
UnknownCRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization.
Not available
S-EPMC9988861 | biostudies-literature
UnknownPreclinical Efficacy and Safety of an Anti-Human VEGFA and Anti-Human NRP1 Dual-Targeting Bispecific Antibody (IDB0076).
Not available
S-EPMC7356919 | biostudies-literature
TranscriptomicsMicroarray analysis of ischemic lesions of WT and TNFRI KO mice
TNF/TNFRI signaling has previously been shown to exert neuroprotective effects after brain ischemic injury. However, the detailed pathways involved remain unidentified. This study aims to identify key neuroprotective molecules activated by TNFRI after permanent ischemic injury in mice. Microarray an...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-8886 | biostudies-arrayexpress
ProteomicsADAMTS18+ telocytes maintain a polarized VEGFA signaling domain and fenestrations in intestinal villus blood vessels
Blood samples from Adamts18 KO and WT mice gavaged with saline, U-13C glucose or protein solution
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-03-18 | MSV000089080 | MassIVE
TranscriptomicsB-ALL GPR65 expression influences susceptibility to CAR-T therapy through a VEGF and macrophage-dependent mechanism [RNA-Seq]
Chimeric antigen receptor (CAR)-T cell therapy has shown promise in treating CD19+ hematological tumors, but some patients fail to respond. Here we used an immune-competent mouse model of B cell acute lymphoblastic leukemia (B-ALL) to assess clonal tumor populations with distinct responses to CAR-T ...
ORGANISM(S): Mus musculus 
2025-01-30 | GSE266240 | GEO
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