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MetabolomicsCold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis
Vein occlusion (VO), including deep venous thrombosis (DVT) and retinal vein occlusion (RVO), is a common cause of multiple diseases that severely compromise the quality of life of affected individuals. Epidemiological evidence indicates that VO prevalence increases in cold seasons, yet the underlyi...
2026-07-08 | MTBLS14667 | MetaboLights
MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
OtherProteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.
Data from ProteomeXchange, PXD ID: PXD001800. File: 6H_02.mzml. Published as part of Exp Eye Res. 2015 Jun 15;138:87-95 . From the Abstract: {{i}} Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the condition remain largely unelucidate...
ORGANISM(S): Pig 
GPM32320017441 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells after pulsed or continuous estradiol exposure
The experiment aims to investigate differences in the transcriptional response of human umbilical vein endothelial cells to estradiol treatment associated with the mode of administration. Human umbilical vein endothelial cells were treated for 5 days with a 1h pulse of 2.4 x 10-8 M 7β-estradiol (E2...
ORGANISM(S): Homo sapiens 
2008-08-29 | E-MEXP-1227 | biostudies-arrayexpress
ProteomicsLong read proteogenomics to characterize protein isoform diversity in human umbilical vein endothelial cells (HUVECs)
Mass spectrometry-based proteomics sample preparation Harvested HUVECs, approximately 5 million cells each, were pelleted and frozen at -80C. The sample pellet was lysed according to the Filter Aided Sample Preparation (FASP) protocol.59 Lysis buffer used in the FASP was changed to 6% SDS, 150 mM DT...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-28 | MSV000089326 | MassIVE
ProteomicsTear proteome revealed association of S100A family proteins and mesothelin with thrombosis in elderly patients with retinal vein occlusion
Tear samples collected from patients with central retinal vein occlusion (n=58) and group of healthy volunteers (n=30) were analyzed using a proteomic label-free absolute quantitative ap-proach. We found a large proportion (458 proteins with a frequency > 0.6) of tear proteome shared between healthy...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD037021 | Pride
Retinal vein occlusion  retinal hemostasis  s100a protein  mesothelin  inflammation 
TranscriptomicsmRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells
mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2. Human umbilical vein endothelial cells (HUVEC) were transfected with 25 nmol/L of control small interfering RNA (siRNA) (Silencer Select Negative Control Ambion, Austin, TX) or siRNA directed against Ezh2 (s4918;...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41610 | biostudies-arrayexpress
TranscriptomicsEffect of from Human Umbilical Vein Endothelial Cells
We profiled global gene expression in primary human umbilical vein endothelial cells to determine the gene expression changes associated with knocking down PKM2 and p53. We identified a p53 dependent transcriptional response that remodels metabolism in cells lacking p53, thus limiting cell growth. H...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-84877 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of caffeic acid phenethyl ester -treated human umbilical vein endothelial cells
This SuperSeries is composed of the following subset Series: GSE10413: Gene expression profiling of caffeic acid phenethyl ester-treated human umbilical vein endothelial cells-1 GSE10429: Gene expression profiling of caffeic acid phenethyl ester -treated human umbilical vein endothelial cells-2 Keyw...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10465 | biostudies-arrayexpress
ProteomicsProteomic evaluation and comparison of native and decellularized human saphenous vein extracellular matrices
This project presents a label-free quantitative proteomic analysis of human saphenous vein (hSV) before and after decellularization, i.e. removal of cellular material using a CHAPS-based protocol. The study evaluated extracellular matrix preservation, vascular basement membrane composition changes, ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD068043 | Pride
Vascular tissue engineering Human saphenous vein Vascular graft Cardiovascular diseases Tissue decellularization Extracellular matrix Vascular basement membrane Regenerative medicine 
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