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Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of som...
ORGANISM(S): Homo sapiens (Human) 
2017-08-09 | PXD005235 | Pride
Infectious Pancreatic Necrosis (IPN) is a highly contagious birnavirus disease of farmed salmonid fish, which often causes high levels of morbidity and mortality. A large genetic component underlying resistance to this disease has been previously described for Atlantic salmon (Salmo salar L.), which...
ORGANISM(S): Salmo salar 
Genomic instability due to defective DNA damage response or arising from mitotic chromosomal imbalance can lead to sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of genomic instability associated diseases and ageing, the catalogue of gen...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD030499 | Pride
In this project we aimed to explore the effect of Dscc1 gene loss on the proteome. Embyros from wildtype and aged matched Dssc1 null embryos were profiled.
ORGANISM(S): Mus musculus (Mouse) 
2023-11-17 | PXD034902 | Pride
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of som...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
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