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ProteomicsYellow protein co-opted to sustain obligate symbiosis in leaf beetles
Yellow proteins are best known for their roles in pigmentation, behavior, and development across insects. Here, we uncover their striking evolutionary co-option for a wholly distinct function: sustaining a Paleocene-aged digestive symbiosis in tortoise beetles. We show that a female-specific Yellow ...
ORGANISM(S): Cassida rubiginosa Aspidimorpha Charidotella sexpunctata Acromis sparsa Chelymorpha gressoria 
2026-06-16 | PXD075214 | Pride
Symbiosis  yellow proteins  lc-ms 
ProteomicsPlacental growth factor mediates pathological uterine vasculature by activating the NFAT5-SGK1 mechano-signaling axis in the endometrium: Implications for pre-eclampsia development.
After menstruation the uterine spiral arteries are repaired through angiogenesis. This process is tightly regulated by the paracrine communication between endometrial stromal cells (EnSCs) and endothelial cells. Any molecular aberration in these processes can lead to complications in pregnancy inclu...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051697 | Pride
Pre-eclampsia Endometrium Sgk1 Pregnancy Placentation Mechanobiology Plgf 
ProteomicsEffect of aberrant PlGF on endometrial stromal cell actin dynamics : implications in pre-eclampsia.
High levels of placental growth factor (PlGF) are pathological, however its function in endometrial cells remains to be investigated. Cell proliferation and motility requires actin reorganization, which is under the control of various signalling pathways including Rac1 and PAK1 proteins. In this stu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050237 | Pride
Actin polymerization Cell stiffness Endometrial cells Angiogenesis Pre-eclampsia. 
ProteomicsAnalysis of S. aureus JE2 ∆cxaR proteome
Analysis of Staphylococcus aureus proteome in the absence of Sle1 negative regulator CxaR. In the absence of CxaR, cellular levels of Sle1 increase nine-fold.
ORGANISM(S): Staphylococcus aureus 
2025-12-15 | PXD066791 | Pride
Lc ms/ms Cxar Proteome Staphylococcus aureus 
ProteomicsLoss of Parkinson’s Disease Protein 7 upregulates cytoskeletal protein Palladin and is associated with pregnancy loss
Decidualization is a morphological and biochemical reprograming process in preparation for pregnancy. An impaired decidual response can lead to complications like recurrent pregnancy loss (RPL). Parkinson’s disease protein 7 (PARK7), which encodes the protein DJ-1, is renowned for its pivotal role i...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD051694 | Pride
Dj-1  palladin  decidualization  recurrent pregnancy loss  endometrium  cytoskeleton 
ProteomicsERK activation waves coordinate mechanical cell competition leading to collective onslaught of bacterially-infected cells
In this study, we investigated how biochemical signaling, and in particular extracellular signal-regulated kinase (ERK) activity waves, coordinate the mechanical battle between Listeria monocytogenes infected and surrounder uninfected epithelial cells. We explored the collective infected cell extrus...
ORGANISM(S): Listeria monocytogenes Canis familiaris (Dog) (Canis lupus familiaris) 
2024-12-18 | PXD055809 | Pride
Host-pathogen interactions Cell competition Collective cell extrusion Listeria monocytogenes Shigella flexneri Zebrafish models Bacterial infection Erk activation waves Cell biomechanics Epithelial cells 
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