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TranscriptomicsTranscription profiling of mouse primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF for 6 hours
PlGF expression profile in primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF during 6 hours.
ORGANISM(S): Mus musculus 
2003-05-28 | E-MEXP-6 | biostudies-arrayexpress
TranscriptomicsPlGF-1 and -2 induce hyperplasia and invasiveness of primary rheumatoid synoviocytes
Inflammation-mediated oncogenesis has been implicated in a variety of cancer types. Rheumatoid synovial tissues can be viewed as a tumor-like mass, consisting of hyperplastic fibroblast-like synoviocytes (FLSs). FLSs of rheumatoid arthritis (RA) patients have pro-migratory and invasive characteristi...
ORGANISM(S): Homo sapiens 
2015-01-14 | E-GEOD-64922 | biostudies-arrayexpress
ProteomicsProteomics reveals ablation of PlGF down-regulate the insulin resistance pathway, increase antioxidant and neuroprotective proteins in the diabetic mice retina
PGF (Placental growth factor) is a member of the vascular endothelial growth factor (VEGF) sub-family a crucial factor in angiogenesis and vasculogenesis. Mechanisms by which PlGF expression is regulated remain to be investigated in diabetic retinopathy DR. However, the underlying molecular mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-13 | PXD010757 | Pride
Akita mice Proteomics Mass spectrometry Diabetes Plgf-knockout 
ProteomicsEffect of aberrant PlGF on endometrial stromal cell actin dynamics : implications in pre-eclampsia.
High levels of placental growth factor (PlGF) are pathological, however its function in endometrial cells remains to be investigated. Cell proliferation and motility requires actin reorganization, which is under the control of various signalling pathways including Rac1 and PAK1 proteins. In this stu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050237 | Pride
Actin polymerization Cell stiffness Endometrial cells Angiogenesis Pre-eclampsia. 
TranscriptomicsmiR-182 modulates myocardial hypertrophic response induced by angiogenesis in heart (MoGene)
Angiogenesis induced by placental growth factor (PlGF) in heart promotes myocardial hypertrophy through the paracrine action of endothelium-derived nitric oxide which triggers the degradation of RGS4 and subsequent the activation of Akt/mTORC1 pathway in cardiomyocytes. However, whether alterations ...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-67815 | biostudies-arrayexpress
TranscriptomicsmiR-182 modulates myocardial hypertrophic response induced by angiogenesis in heart (miRNA)
Angiogenesis induced by placental growth factor (PlGF) in heart promotes myocardial hypertrophy through the paracrine action of endothelium-derived nitric oxide which triggers the degradation of RGS4 and subsequent activation of the Akt/mTORC1 pathway in cardiomyocytes. However, whether alterations ...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-67814 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVECs treated with the angiogenic factors VEGF-A and PlGF in low or high serum media
HUVECs (human umbilical cord vein endothelial cells) are treated with the angiogenic factors VEGF-A (vascular endothelial growth factor-A) and PlGF (placental growth factor) in low or high serum media.
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-837 | biostudies-arrayexpress
ProteomicsPlacental Growth Factor Regulates the Pentose Phosphate Pathway and Antioxidant Defense Systems in Human Retinal Endothelial Cells
The molecular mechanisms whereby placental growth factor (PlGF) mediates its effects in nonproliferative diabetic retinopathy (DR) are unknown. To better understand the role of PlGF in DR, we used tandem mass tags (TMT)-labeled quantitative proteomics to human retinal endothelial cells (HRECs), tre...
ORGANISM(S): Homo sapiens (Human) 
2020-03-17 | PXD017195 | Pride
Tmt Prdx6 Kegg Plgf Ppp 
TranscriptomicsPlacental growth factor as potential target against hepatocellular carcinoma in an orthotopic mouse model.
The placental growth factor (PlGF) is member of the vascular endothelial growth factor (VEGF)-family known to stimulate endothelial cell growth, migration and survival, attract angiocompetent macrophages and bone marrow progenitor cells and determine the metastatic niche. Unlike VEGF, genetic studie...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-35289 | biostudies-arrayexpress
ProteomicsPlacental growth factor mediates pathological uterine vasculature by activating the NFAT5-SGK1 mechano-signaling axis in the endometrium: Implications for pre-eclampsia development.
After menstruation the uterine spiral arteries are repaired through angiogenesis. This process is tightly regulated by the paracrine communication between endometrial stromal cells (EnSCs) and endothelial cells. Any molecular aberration in these processes can lead to complications in pregnancy inclu...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051697 | Pride
Pre-eclampsia Endometrium Sgk1 Pregnancy Placentation Mechanobiology Plgf 
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