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ProteomicsMultiplicity of regulatory subunit conformations define structural ensemble of reset Protein Kinase A holoenzyme
How Protein kinase A (PKA) is reset to a basal state following 3’5’cyclic adenosine monophosphate(cAMP)-mediated activation is unknown. Here we describe the mechanism of cAMP-PKA signal termination leading to reset of PKA by holoenzyme formation through the obligatory action of phosphodiesterases (P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-07-14 | PXD061315 | Pride
Reset Conformational dynamics Signal termination Phosphodiesterase Protein kinase a 
ProteomicsA Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway
The Hedgehog (Hh) signaling pathway is fundamental to embryogenesis, tissue homeostasis, and cancer. Hh signals are transduced via an unusual mechanism: upon agonist-induced phosphorylation, the noncanonical G protein-coupled receptor SMOOTHENED (SMO) binds the catalytic subunit of protein kinase A ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD067578 | Pride
Smoothened Protein kinase a Hedgehog 
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