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ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
UnknownA Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.
Not available
S-EPMC5457488 | biostudies-literature
UnknownBRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance.
Not available
S-EPMC8356021 | biostudies-literature
Unknownp53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.
Not available
S-EPMC4601526 | biostudies-literature
UnknownContinuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis.
Not available
S-EPMC3107272 | biostudies-literature
UnknownA-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.
Not available
S-EPMC3642183 | biostudies-literature
UnknownCancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance.
Not available
S-EPMC8191791 | biostudies-literature
UnknownThe carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.
Not available
S-EPMC2719694 | biostudies-literature
UnknownZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.
Not available
S-EPMC6976523 | biostudies-literature
ProteomicsImpact of alternative splicing on the human proteome
Alternative splicing is a critical determinant of genome complexity and by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, we have developed an integrative approach to ask whether dynamic perturbations ...
ORGANISM(S): Homo sapiens (Human) 
2017-08-02 | PXD003278 | Pride
Alternative splicing Swath Proteome Prpf8 
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