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MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
TranscriptomicsTranscription profiling of human peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension
Microarray analysis of peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension.
ORGANISM(S): Homo sapiens 
2007-09-21 | E-GEOD-703 | biostudies-arrayexpress
TranscriptomicsAcute venous hypertension induces local release of inflammatory cytokines and endothelial activation in humans
Background: Venous hypertension is often present in advanced and in acute decompensated heart failure (HF). However, it is unclear whether high intravenous pressure can cause alterations in homeostasis by promoting inflammation and endothelial cell (EC) activation. We used an experimental model of a...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-38783 | biostudies-arrayexpress
TranscriptomicsMetabolomic heterogeneity of severe pulmonary arterial hypertension
Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular sy...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-53408 | biostudies-arrayexpress
ProteomicsExtracellular Matrix Analysis of Human Varicose Veins
To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-17 | MSV000080062 | MassIVE
TranscriptomicsHypoxic pulmonary hypertension study
These microarray studies were performed using whole lungs of BALB/C mice during development of hypoxia-induced pulmonary hypertension (days 1-21) and resolution of pulmonary hypertension after return to normoxia (days 22-35) . Mice were sampled during nine time-points and each time-point was replic...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-1909 | biostudies-arrayexpress
TranscriptomicsMurine Schistosoma-Induced Pulmonary Hypertension: RNA-seq Data
Whole lung RNA-seq of 8 mice with experimental Schistosoma-induced pulmonary hypertension, compared to 8 control mice. All mice on a C57Bl6/J background. 3 schisto-PH and 3 control mice (#s 1-3 in each group) were also processed by Affy microarray and separately submitted. 3 of the mice in each grou...
ORGANISM(S): Mus musculus 
2013-07-23 | E-GEOD-49114 | biostudies-arrayexpress
TranscriptomicsLongitudinal analysis of developing neointimal vascular proliferation and pulmonary hypertension in rats
6 timepoints: Day 0 (normal controls), progressively developing neointimal vascular proliferation and pulmonary hypertension in vehicle treated animals (Days 14, 21, 28 and 35) and triptolide-treated animals at Day 35. Replicates: 6 for Day 0 (normal) 2 for Daty 14 3 each for Days 21, 28, 35 and Tr...
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-843 | biostudies-arrayexpress
TranscriptomicsMurine Schistosoma-Induced Pulmonary Hypertension: Microarray Data
Rationale: Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathways that play protective or pathogenic ro...
ORGANISM(S): Mus musculus 
2013-07-16 | E-GEOD-48936 | biostudies-arrayexpress
TranscriptomicsArterial vs venous expression of genes: differences in inflammatory genes
Arteries and veins modulate cardiovascular homeostasis and contribute to the pathogenesis of hypertension. Functional differences between normal arteries and veins are based upon differences in gene expression. To better characterize these expression patterns, and to identify candidate genes that ...
ORGANISM(S): Rattus norvegicus 
2009-07-13 | E-GEOD-12255 | biostudies-arrayexpress
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