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TranscriptomicsTranscription profiling of right ventricule from arrhythmogenic heterozygous plakoglobin deficient mice undergone endurance training to identify transcriptional responses to training.
Endurance training accelerated development of right ventricular dysfunction and arrhythmias in plakoglobin+/- mice. Histology and electron microscopy did not identify right ventricular abnormalities. To identify differences in the transcriptional response to training gene expression profiling was pe...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4120 | biostudies-arrayexpress
MetabolomicsIntegrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue

Barth syndrome (BTHS) is a rare X-linked recessively inherited disorder caused by variants in the TAFAZZIN gene. The pathogenic variants lead to impaired conversion of monolysocardiolipin (MLCL) into mature phospholipid cardiolipin (CL). The accumulation of MLCL and mature CL deficiency is a diag...

2025-09-08 | MTBLS12953 | MetaboLights
TranscriptomicsMutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
Left ventricular noncompaction (LVNC) Causes prominent ventricular trabeculations and reduces cardiac systolic function. The clinical presentation of LVNC ranges from asymptomatic to heart failure. We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin liga...
ORGANISM(S): Mus musculus 
2015-08-10 | E-GEOD-71912 | biostudies-arrayexpress
MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
ProteomicsProteomic analysis of right-ventricular dysfunction (RVD) in patients with advanced chronic heart failure.
This research aimed to identify protein biomarkers of right ventricular dysfunction in patients with advanced heart failure with reduced ejection fraction (HFrEF). Samples of myocardium from both, right and left ventricles (RV, LV) were obtained from 10 HFrEF patients with right ventricular dysfunct...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD043768 | Pride
Myocardium Right ventricular dysfunction Lfq Triton x-100 Chronic heart failure Biomarkers Rvd 
GenomicsStudies of Left Ventricular Dysfunction (SOLVD-BioLINCC)
Studies of Left Ventricular Dysfunction (SOLVD-BioLINCC)
PRJNA1120513 | ENA
GenomicsStudies of Left Ventricular Dysfunction (SOLVD-BioLINCC)
Studies of Left Ventricular Dysfunction (SOLVD-BioLINCC)
PRJNA1120512 | ENA
ProteomicsMyeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation
This project characterizes chamber-specific proteomic remodeling in a murine three-hit HFpEF model that develops right ventricular dysfunction, using chow, hypoxia alone, and HFD+L-NAME as control conditions. The three-hit model (hypoxia, high-fat diet, and L-NAME) recapitulates key features of huma...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD074772 | Pride
Heart Mouse Hfpef Hypoxia 
TranscriptomicsLeft ventricular myocardial transcriptomic profiling for target discovery in a rat model of pressure overload-induced heart failure
Left ventricular myocardial transcriptomic profiling was performed in rats subjected to transverse aortic constriction (TAC)-induced heart failure and sham-operated controls to investigate gene expression changes associated with pressure overload-induced cardiac remodeling. The dataset was used in s...
ORGANISM(S): Rattus norvegicus 
2026-06-11 | E-MTAB-17114 | biostudies-arrayexpress
TranscriptomicsBulk RNAseq of anti-PD1-induced cardiac dysfunction in C57BL/6J mice
C57BL6/J mice were treated with anti-PD-1 for 2 or 4 weeks, or with isotype control antibody. In echocardiography, cardiac dysfunction was seen both after 2 and 4 weeks, with decreased ejection fraction and left ventricular dilation. Bulk RNA sequencing of the hearts after treatment was performed to...
ORGANISM(S): Mus musculus 
2022-12-03 | E-MTAB-12388 | biostudies-arrayexpress
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