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Transcriptional profile of inbreeding depression expressing as extreme cold-sensitivity. The experiment is a crossdesign of a conditional lethal line and an inbred control line, at permissive and a restrictive conditions (the latter involving a cold shock)
ORGANISM(S): Drosophila melanogaster 
Polycomb repression of gene expression is critical for development, with a pivotal role for trimethylation of lysine 27 of histone H3 (H3K27me3) deposited by Polycomb Repressive Complex 2 (PRC2). While the function and regulation of PRC2 have been extensively studied, the mechanism(s) by which it is...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-07 | PXD005821 | Pride
The Nucleosome Remodeling and Deacetylase (NuRD) complex plays an important role in gene expression regulation, stem cell self-renewal, and lineage commitment. Yet little is known about the dynamics of NuRD during cellular differentiation. Here, we study these dynamics using genome-wide profiling an...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-11 | PXD010512 | Pride
Diclofenac is a widely used analgesic drug that can cause serious adverse drug reactions. We used Saccharomyces cerevisiae as model eukaryote to elucidate the molecular mechanisms of diclofenac toxicity and resistance. Although most yeast cells died during initial diclofenac treatment, some survived...
ORGANISM(S): Saccharomyces cerevisiae 
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