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TranscriptomicsPharmacogenomics of IFNb therapy
This experiment set is used for the manuscript entitled: Pharmacogenomics of Interferon-b therapy in multiple sclerosis: Baseline IFN signature determines pharmacological differences between patients. In this study we generated and analyzed pre- and post- IFNb treatment gene expression patterns of R...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-10655 | biostudies-arrayexpress
TranscriptomicsRheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from th...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19821 | biostudies-arrayexpress
TranscriptomicsInduction of dnTCF-4 in Ls174T CRC cells
The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the primary transforming event in colorectal cancer (CRC). We show that disruption of beta-catenin/TCF-4 activity in CRC cells induces a rapid G1 arrest and blocks a genetic program that is physiologically active in...
ORGANISM(S): Homo sapiens 
2005-09-10 | E-GEOD-3282 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Ls174T CRC cells with induced of dnTCF-4
The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the primary transforming event in colorectal cancer (CRC). We show that disruption of beta-catenin/TCF-4 activity in CRC cells induces a rapid G1 arrest and blocks a genetic program that is physiologically active in...
ORGANISM(S): Homo sapiens 
2005-09-02 | E-SMDB-1723 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of rheumatoid arthritis synovial tissues
Spots were selected that had an expression level higher than 1.6 the local background. The use of a common reference sample allows the comparison of the relative expression levels across the tissue samples. All genes were expressed relative to their median expression level across the arrays of the s...
ORGANISM(S): Homo sapiens 
2007-09-13 | E-GEOD-9027 | biostudies-arrayexpress
TranscriptomicsRheumatoid arthritis and rheumatoid synovium
Rheumatoid arthritis (RA) is a heterogeneous disease. We used cDNA microarray technology to subclassify RA patients and disclose disease pathways in rheumatoid synovium. Hierarchical clustering of gene expression data identified two main groups of tissues (RA-I and RA-II). A total of 121 genes were ...
ORGANISM(S): Homo sapiens 
2005-12-14 | E-GEOD-3824 | biostudies-arrayexpress
TranscriptomicsFibroblast-like synoviocytes derived from patients with rheumatoid arthritis
Fibroblast-like synoviocytes (FLS) were cultured from synovial tissues from 19 RA patients. RNA was isolated using the Fast Track 2.0 kit (Invitrogen, Carlsbad, California)from the FLS cultures. Fluorescent cDNA probes were prepared from 1 ug experimental mRNA by oligo dT-primed polymerization using...
ORGANISM(S): Homo sapiens 
2006-01-18 | E-GEOD-4061 | biostudies-arrayexpress
TranscriptomicsArthritis and Rheumatism
Synovial tissue mRNA from 21 RA patients and 9 OA patients is hybridized against a common reference sample on lymphochips. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Using regression correlation
ORGANISM(S): Homo sapiens 
2005-12-16 | E-GEOD-3848 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors (discovery)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-45359 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors (validation)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-45363 | biostudies-arrayexpress
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