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TranscriptomicsRNA-seq of human neuroblastoma cell lines where RET is knocked out
ALK is driving neuroblastoma (NB) and RET has been shown to be a downstream target of ALK signaling in NB. To get a better understanding of the role of RET in NB, the gene was knocked out in SKNAS cell lines.
ORGANISM(S): Homo sapiens 
2021-04-14 | E-MTAB-10032 | biostudies-arrayexpress
UnknownNUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner.
Not available
S-EPMC6927325 | biostudies-literature
UnknownLoss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells.
Not available
S-EPMC8071449 | biostudies-literature
UnknownThe neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo.
Not available
S-EPMC3140014 | biostudies-literature
ProteomicsLoss of RET promotes mesenchymal identity in neuroblastoma cells
Aberrant activation of Anaplastic Lymphoma Kinase (ALK) drives neuroblastoma (NB). Previous work has identified the RET receptor tyrosine kinase (RTK) as a downstream target of ALK activity in NB models. We show here that ALK activation in response to ALKAL2 ligand results in the rapid phosphorylati...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024551 | Pride
Alk Alkal2 Emt Adrenergic Retinoic acid Neural differentiation 
UnknownTumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.
Not available
S-EPMC5589087 | biostudies-literature
UnknownInternalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.
Not available
S-EPMC3316580 | biostudies-literature
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