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GenomicsRNA-seq of human neuroblastoma cell lines treated with ALKAL2 and/or lorlatinib
RNA-seq of human neuroblastoma cell lines treated with ALKAL2 and/or lorlatinib
PRJEB40483 | ENA
UnknownThe neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain.
Not available
S-EPMC9197515 | biostudies-literature
GenomicsRNA-seq of TH-MYCN driven neuroblastoma mice +/- ALK F1178S mutation and +/- ALKAL2 overexpression
RNA-seq of TH-MYCN driven neuroblastoma mice +/- ALK F1178S mutation and +/- ALKAL2 overexpression
PRJEB40634 | ENA
UnknownNeuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.
Not available
S-EPMC12184428 | biostudies-literature
UnknownALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Not available
S-EPMC7849294 | biostudies-literature
TranscriptomicsRNA-seq of human neuroblastoma cell lines treated with ALKAL2 and/or lorlatinib
ALK is a tyrosine kinase receptor and oncogene in neuroblastoma (NB). The receptor is activated by the ALKAL2 ligand, but it is unknown whether missregulation of this ligand may play a role in NB carcinogenesis. To characterize the transcriptomic response to ALKAL2 in neuroblastoma cell lines, RNA-...
ORGANISM(S): Homo sapiens 
2020-11-24 | E-MTAB-9598 | biostudies-arrayexpress
TranscriptomicsRNA-seq of TH-MYCN driven neuroblastoma mice +/- ALK F1178S mutation and +/- ALKAL2 overexpression
ALK is a tyrosine kinase receptor and oncogene in neuroblastoma (NB). The receptor is activated by the ALKAL2 ligand, but it is unknown whether missregulation of this ligand may play a role in NB carcinogenesis. Here, a TH-MYCN driven neuroblastoma mice was created +/- ALK F1178S mutation and +/- AL...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9600 | biostudies-arrayexpress
UnknownThe autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer.
Not available
S-EPMC8962179 | biostudies-literature
GenomicsThe neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain
The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain
PRJNA830461 | ENA
ProteomicsProteomics and phosphoproteomics on NB1 and IMR32 neuroblastoma cells stimulated with ALAKAL2
High-risk neuroblastoma (NB) is notoriously difficult to treat and is responsible for a disproportionate number of childhood deaths due to cancer. One long accepted indicator of high-risk NB and poor prognosis is amplification of the neural MYC (MYCN) oncogene, which is currently therapeutically int...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD021792 | Pride
Neuroblastoma Cancer Nb Tmt Anaplastic lymphoma kinase Phosphorylation Alkal2 Tandem mass tag Alk 
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