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MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
TranscriptomicsTMV-derived Small RNAs Reveals Role for Arabidopsis thaliana RNA-dependent RNA Polymerases in Viral siRNA Biogenesis
Using a crucifer-infecting strain of Tobacco Mosaic Virus (TMV-Cg) and Arabidopsis thaliana as a model system, we analyzed the viral small RNA profile in wild-type plants as well as rdr mutants by applying small RNA deep sequencing technology. Over 100,000 TMV-Cg-specific small RNA reads, mostly of...
ORGANISM(S): Youcai mosaic virus 
2009-03-24 | E-GEOD-12918 | biostudies-arrayexpress
ProteomicsSARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future vi...
ORGANISM(S): Homo Sapiens 
2022-09-28 | PXD037068 |
ProteomicsInfluenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3' and 5' vRNA ends (the promoter). In recent structures of promoter-bound polymerase, the cap-binding and endo...
ORGANISM(S): Influenza B virus (B/Memphis/13/03) Influenza A virus (A/Vietnam/1203/04(H5N1)) 
2016-01-04 | PXD002234 | Pride
Influenza Xl-ms Polymerase 
UnknownThe uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase.
Not available
S-EPMC5711473 | biostudies-literature
UnknownThe RNA-dependent RNA polymerase of enterovirus A71 associates with ribosomal proteins and positively regulates protein translation.
Not available
S-EPMC7237135 | biostudies-literature
TranscriptomicsIdentification of novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus
While numerous viral microRNAs (miRNAs) expressed by DNA viruses, especially herpesvirus family members, have been reported, there have been very few reports of miRNAs derived from RNA viruses. Here we describe three miRNAs expressed by bovine foamy virus (BFV), a member of the spumavirus subfamily ...
ORGANISM(S): Bos taurus 
2015-04-07 | E-GEOD-67620 | biostudies-arrayexpress
UnknownA viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity.
Not available
S-EPMC3273391 | biostudies-literature
UnknownCytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8.
Not available
S-EPMC4072778 | biostudies-literature
UnknownIdentification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication.
Not available
S-EPMC5016140 | biostudies-literature
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